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Related Experiment Video

Updated: Jun 1, 2026

Detrusor Underactivity Model in Rats by Conus Medullaris Transection

Detrusor Underactivity Model in Rats by Conus Medullaris Transection

Published on: August 28, 2020

Sophisticated models and methods for studying neurogenic bladder dysfunction.

Anthony Kanai¹, Irina Zabbarova, Youko Ikeda

¹Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. ajk5@pitt.edu

Neurourology and Urodynamics

|June 11, 2011

Summary

This summary is machine-generated.

New animal models and methods enable studying neurogenic bladder overactivity mechanisms. This research investigates peripheral and central pathways, offering insights into incontinence and detrusor overactivity.

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Published on: November 28, 2019

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Last Updated: Jun 1, 2026

Detrusor Underactivity Model in Rats by Conus Medullaris Transection

Detrusor Underactivity Model in Rats by Conus Medullaris Transection

Published on: August 28, 2020

A Decentralized (Ex Vivo) Murine Bladder Model with the Detrusor Muscle Removed for Direct Access to the Suburothelium during Bladder Filling

A Decentralized (Ex Vivo) Murine Bladder Model with the Detrusor Muscle Removed for Direct Access to the Suburothelium during Bladder Filling

Published on: November 28, 2019

Area of Science:

Urology
Neuroscience
Animal Models

Background:

Neurogenic bladder overactivity is a complex condition with poorly understood underlying mechanisms.
Current research requires advanced models to investigate both peripheral and central nervous system contributions.

Purpose of the Study:

To detail novel and existing animal models and methodologies for studying the mechanisms of neurogenic bladder overactivity.
To generate critical experimental data for a comprehensive understanding of this condition.

Main Methods:

Utilized irradiated mice and those with motor neuron lesions (upper and lower).
Employed cystometry, tension measurements, afferent nerve recordings, and optical mapping of action potentials and Ca(2+) transients.
Investigated innovative preparations including cultured cells, bladder-urethra sheets, spinal cord slices, and cerebral cortex.

Main Results:

Models allowed study of peripheral and central mechanisms of neurogenic overactivity.
Colonic irradiation induced neurogenic dysfunction; spinal cord lesions caused non-neural changes and stimulated afferent nerves.
Imaging revealed spontaneous firing in bladder interstitial cells and identified central pathway changes in the spinal cord and brain.

Conclusions:

The described models facilitate studying neurogenic overactivity at peripheral, spinal, and cortical levels.
Enhanced understanding of sensory/motor mechanisms in incontinence is anticipated.
The roles of interstitial cells, spontaneous detrusor contractions, and cortical involvement can be further elucidated.