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Updated: Jun 1, 2026

Microfluidics-based High-throughput Circulating Tumor Cell Sorting and Single-cell Sequencing Technology

Microfluidics-based High-throughput Circulating Tumor Cell Sorting and Single-cell Sequencing Technology

Published on: November 14, 2025

Single-cell-level microplasma cancer therapy.

Jae Young Kim¹, Yanzhang Wei, Jinhua Li

¹Holcombe Department of Electrical and Computer Engineering, Center for Optical Materials Science and Engineering Technologies (COMSET), Clemson University, Clemson, SC 29634, USA.

Small (Weinheim an Der Bergstrasse, Germany)

|June 11, 2011

Summary

This summary is machine-generated.

A novel flexible microplasma endoscope was developed using optical fiber. This technology shows promise for targeted cancer therapies by inducing tumor cell death and exhibiting antitumor activity in animal models.

Keywords:

antitumor agents cancer therapy microplasma jets optical fibers plasma medicine

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Clinical Microfluidic Chip Platform for the Isolation of Versatile Circulating Tumor Cells

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Area of Science:

Biomedical Engineering
Plasma Physics
Oncology

Background:

Targeted cancer therapies require precise delivery of therapeutic agents.
Minimally invasive endoscopic tools are crucial for in-situ cancer treatment.
Microplasma technology offers potential for localized biological effects.

Purpose of the Study:

To fabricate a flexible microplasma endoscope for potential cancer therapy.
To evaluate the apoptotic effects of microplasma on tumor cells.
To assess the antitumor activity of the microplasma jet in vivo.

Main Methods:

Fabrication of a flexible microplasma endoscope utilizing a 15 μm hollow-core glass optical fiber.
Analysis of tumor cell apoptosis induced by the microplasma.
In vivo animal studies to evaluate antitumor effects at varying plasma doses.

Main Results:

Successful fabrication of a flexible microplasma endoscope.
Demonstrated induction of tumor cell apoptosis.
Observed significant antitumor activity in animal models at specific plasma doses.

Conclusions:

The developed optical-fiber microplasma endoscope is a viable tool for targeted cancer therapy.
Microplasma treatment shows efficacy in inducing tumor cell death and reducing tumor burden.
Further research is warranted to optimize plasma parameters for clinical translation.