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Updated: Jun 1, 2026
09:34
An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis
Published on: August 16, 2021
[Neuropsychiatric side effects of antituberculosis agents]
L Fekih1, L Boussoffara, S Fenniche
1Service de Pneumologie, Ibn Nafiss, Hôpital Abderrahmen Mami, Ariana, 2080 Tunisia.
Revue Medicale De Liege
|June 14, 2011
Summary
Neuropsychiatric complications from antituberculosis drugs, particularly isoniazid, are common. Close patient monitoring and dose adjustment or discontinuation of isoniazid are crucial for favorable outcomes.
Area of Science:
- Neurology
- Psychiatry
- Pharmacology
Context:
- Antituberculosis drugs can cause neurological or psychiatric complications.
- These complications pose diagnostic and therapeutic challenges.
Purpose:
- To study the frequency, clinical presentations, and therapeutic approaches of neuropsychiatric complications associated with antituberculosis treatment.
Summary:
- A retrospective study of 18 patients revealed peripheral neuropathy (33%), convulsions (2 cases), hallucinosis (4 cases), and other behavioral issues (6 cases). Isoniazid was implicated in all cases.
- Management involved dose adjustment or discontinuation of isoniazid, B6 vitamin supplementation, and anticonvulsants or anxiolytics as needed.
- All 18 patients experienced favorable outcomes with appropriate interventions.
Impact:
- Highlights the importance of monitoring patients on antituberculosis therapy for neuropsychiatric side effects.
- Emphasizes the role of isoniazid as a common culprit and the necessity of individualized treatment adjustments.
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