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Updated: Jun 1, 2026
08:20
A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome
Published on: October 2, 2018
An uncommon etiology for a common problem: hirsutism.
Emily Winterton1, Kathleen Eyster, Keith A Hansen
1Sanford School of Medicine, The University of South Dakota, USA.
Summary
Sudden, rapid hirsutism in women may signal a rare androgen-producing ovarian tumor. Prompt diagnosis is crucial for patients with virilizing signs and elevated testosterone, even with normal initial imaging.
Area of Science:
- Endocrinology
- Gynecologic Oncology
Background:
- Hirsutism is common, often benign.
- Rapidly progressive hirsutism with virilizing signs suggests androgen-producing neoplasms.
Observation:
- A 28-year-old female presented with acute onset hirsutism and virilizing signs.
- Markedly elevated serum testosterone was noted.
- Initial adrenal and ovarian imaging appeared normal.
Findings:
- A rare steroid-secreting ovarian tumor was diagnosed.
- This tumor was the cause of the patient's symptoms.
Implications:
- Highlights the need for high suspicion of androgen-producing neoplasms in specific clinical presentations.
- Emphasizes thorough investigation despite normal initial imaging for virilizing symptoms.
- Underscores the importance of considering rare ovarian tumors in the differential diagnosis.
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