Related Experiment Video
Updated: Jun 1, 2026

06:09
Optic Nerve Sheath Point of Care Ultrasound: Image Acquisition
Published on: August 18, 2023
Idiopathic dural optic nerve sheath calcification associated with choroidal osteoma
Francisco J Ascaso1, Rafael Lasierra
1Department of Ophthalmology, Lozano Blesa University Clinic Hospital, Zaragoza, Spain. jascaso@gmail.com
Summary
This study reports a rare case of choroidal osteoma with optic nerve calcifications and other intracranial calcifications, observed over 16 years without progression. The findings suggest a generalized dural calcification process potentially linked to intraocular inflammation.
Area of Science:
- Ophthalmology
- Neurology
- Radiology
Background:
- Choroidal osteomas are rare benign ossifying tumors of the choroid.
- Optic nerve sheath calcification is an uncommon finding, often associated with systemic conditions.
- Generalized intracranial calcifications can indicate various underlying pathologies.
Observation:
- A 28-year-old woman presented with a choroidal osteoma in the right eye and left optic atrophy.
- Associated findings included bilateral optic nerve sheath calcification and calcifications in the pineal gland, choroid plexus, and dura.
- Imaging and visual acuity remained stable over a 16-year follow-up period.
Findings:
- The combination of optic nerve sheath calcification and multiple intracranial calcifications suggests a generalized dural calcification process.
- This is the first reported case of a choroidal ossifying tumor associated with calcified optic nerve lesions.
- The pathogenesis of bone formation in choroidal osteoma is uncertain, with intraocular inflammation proposed as a potential factor.
Implications:
- This case expands the understanding of rare ophthalmic and neurological associations.
- It highlights the importance of comprehensive imaging in cases of choroidal osteoma.
- Further research is needed to elucidate the etiology of combined intraocular and intracranial calcifications.
Related Concept Videos
Glaucoma: Overview
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
Open Angle Glaucoma: Treatment
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
Angle Closure Glaucoma: Treatment
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
Cushing Syndrome II: Pathophysiology
Cortisol production is normally governed by the hypothalamic–pituitary–adrenal (HPA) axis, which maintains hormonal balance through tightly regulated feedback mechanisms. Disruption of this regulatory system is central to the development of Cushing syndrome, whether the excess cortisol originates from external medications or internal pathology. Persistent cortisol elevation alters metabolism, immune function, and endocrine signaling, producing the characteristic clinical features of the...