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[Enzymatic digestibility of peptides containing tert-butyltryptophan residues (author's transl)]
Hoppe-Seyler'S Zeitschrift Fur Physiologische Chemie
|January 1, 1979
Abstract:
The effects of tert-butylation of tryptophan residues in peptide chains on the enzymatic digestibility were investigated. It was shown that replacement of tryptophan in position 9 of Corticotropin-(1--19)-nonadecapeptidamide by a mono- or tri-tert-butylated tryptophan enhances the resistance of the resulting analogue against proteolytic enzymes.