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Related Experiment Video

Updated: Jun 1, 2026

Using a Cyclic Ion Mobility Spectrometer for Tandem Ion Mobility Experiments

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Published on: January 20, 2022

Surface ionization ion mobility spectrometry.

C Wu¹, H H Hill, U K Rasulev

¹Department of Chemistry, Washington State University, Pullman, Washington 99164-4630.

Analytical Chemistry

|June 14, 2011

Summary

This summary is machine-generated.

A new surface ionization source for ion mobility spectrometry offers a nonradioactive, selective, and reliable alternative to traditional methods. This advancement achieves picogram detection limits and a wide dynamic range for various compounds.

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T-wave Ion Mobility-mass Spectrometry: Basic Experimental Procedures for Protein Complex Analysis

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Published on: July 31, 2010

Area of Science:

Analytical Chemistry
Spectrometry

Background:

Traditional ionization sources like Nickel-63 present regulatory challenges.
There is a need for nonradioactive, reliable ionization sources in spectrometry.

Purpose of the Study:

To design and construct a surface ionization source for ion mobility spectrometry.
To evaluate the performance and advantages of the novel SI-IMS.

Main Methods:

Development of a surface ionization (SI) source for ion mobility spectrometry (IMS).
Performance evaluation using triethylamine, amines, tobacco alkaloids, and triazine herbicides.
Analysis of source conditions and gaseous environments.

Main Results:

The SI-IMS demonstrated high selectivity and a 5-order dynamic response range.
Picogram detection limits were achieved for target analytes.
The SI source is simple, reliable, and avoids regulatory issues of radioactive sources.

Conclusions:

Surface ionization is a viable, nonradioactive alternative for IMS detection of specific compound classes.
The SI-IMS offers improved selectivity and dynamic range compared to (63)Ni sources for applicable analytes.