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Primary Culture of Human Vestibular Schwannomas

Primary Culture of Human Vestibular Schwannomas

Published on: July 20, 2014

Schwann cell hamartoma: case report.

Elena Guerini Rocco¹, Francesca Iannuzzi, Alessandra Dell'Era

¹Department of Medicine, Surgery and Dentistry, Division of Pathology, A,O, San Paolo and Fondazione IRCCS Cà-Granda Ospedale Maggiore Policlinico, University of Milan Medical School, Milan, Italy.

BMC Gastroenterology

|June 14, 2011

Summary

Colorectal polyps can originate from mesenchymal tissue. A rare case of a benign mucosal Schwann cell hamartoma was identified, distinct from schwannoma.

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Area of Science:

Gastroenterology
Surgical Pathology
Oncology

Background:

Colorectal polyps of mesenchymal origin are uncommon gastrointestinal (GI) lesions.
Their detection is increasing due to widespread colonoscopy screening.

Observation:

A case of a small colonic polyp presented as an intramucosal diffuse spindle cell proliferation.
The lesion exhibited benign cytology and strong, diffuse S-100 protein immunoreactivity.
A pure Schwann cell phenotype was identified.

Findings:

Morphological, immunohistochemical, and clinical evaluations differentiated this lesion from other stromal colonic lesions.
The findings distinguished it from schwannoma, a rare benign nerve sheath tumor in the GI tract.

Implications:

This case supports the recent proposal to classify this lesion as a mucosal Schwann cell hamartoma.
Accurate diagnosis is crucial for differentiating this benign hamartoma from other mesenchymal tumors of the colon.