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Updated: Jun 1, 2026
Primary Culture of Human Vestibular Schwannomas
Published on: July 20, 2014
Schwann cell hamartoma: case report
Elena Guerini Rocco1, Francesca Iannuzzi, Alessandra Dell'Era
1Department of Medicine, Surgery and Dentistry, Division of Pathology, A,O, San Paolo and Fondazione IRCCS Cà-Granda Ospedale Maggiore Policlinico, University of Milan Medical School, Milan, Italy.
Background:
Colorectal polyps of mesenchymal origin represent a small percentage of gastrointestinal (GI) lesions. Nevertheless, they are encountered with increasing frequency since the widespread adoption of colonoscopy screening.
Case Presentation:
We report a case of a small colonic polyp that presented as intramucosal diffuse spindle cell proliferation with a benign cytological appearance, strong and diffuse immunoreactivity for S-100 protein, and pure Schwann cell phenotype. Careful morphological, immunohistochemical and clinical evaluation emphasize the differences from other stromal colonic lesions and distinguish it from schwannoma, a circumscribed benign nerve sheath tumor that rarely arises in the GI tract.
Conclusion:
As recently proposed, this lesion was finally described as mucosal Schwann cell hamartoma.
