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Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure
Published on: June 10, 2025
[Prognostic factors and long-term survival after initial diagnosis of heart failure]
Raúl Quirós López1, Javier García Alegría, María Dolores Martín Escalante
1Unidad de Medicina Interna, Área de Medicina, Hospital Costa del Sol, Marbella, Málaga, España. quiroslopez77@gmail.com
Insights
Heart failure patients face high mortality within 10 years. Key risk factors include age, diabetes, heart disease, and kidney failure. Beta-blockers and statins may improve outcomes for heart failure patients.
Area of Science:
- Cardiology
- Clinical Research
- Public Health
Context:
- Heart failure (HF) is a major cause of morbidity and mortality worldwide.
- Distinguishing between heart failure with preserved ejection fraction (HFPEF) and heart failure with systolic dysfunction (HFSD) is crucial for understanding prognosis.
- Long-term outcomes and prognostic factors in incident HF cases require further investigation.
Purpose:
- To evaluate long-term mortality and identify prognostic factors in patients with newly diagnosed heart failure.
- To analyze differences in outcomes between HFPEF and HFSD.
- To compare findings with existing literature on incident heart failure cases.
Summary:
- A retrospective cohort study followed 400 incident heart failure patients for 10 years.
- Mortality rates were higher in the HFSD group (64.5%) compared to the HFPEF group (55.4%).
- Independent predictors of mortality included age, diabetes mellitus, ischemic heart disease, and chronic renal failure. Beta-blocker and statin use were associated with improved survival.
Impact:
- Over half of heart failure patients die within a decade of diagnosis.
- Identifying specific risk factors allows for targeted interventions and improved patient management.
- This study provides valuable insights into the long-term prognosis of different heart failure subtypes and the impact of specific treatments.
Background And Objective:
To assess long-term mortality and prognostic factors after initial diagnosis of heart failure (HF), to analyze the differences in function of the left ventricular ejection fraction (preserved [HFPEF] vs. systolic dysfunction [HFSD]) and to compare the results with the main series of incident cases of HF published.
Patients And Methods:
Retrospective cohort study including patients first diagnosed of heart failure (Framingham criteria), between 1-01-1997 and 31-12-2001, classified according to a left ventricle ejection fraction (LVEF) above or equal to 50% (HFPEF) or below 50% (HFSD). Follow-up of patients was conducted during ten years.
Results:
Out of 400 incident cases of heart failure, 231 patients (57,7%) presented with HFPEF. At 10 years, mortality rates were higher in the HFSD group (64,5 vs. 55,4%, p=0,04). Following a multi-variant analysis, HFPEF mortality was related with age, diabetes mellitus, ischemic heart disease, and chronic renal failure. Treatment with statins and beta-blockers was associated with improved prognosis. Among patients with HFSD, mortality predictors were similar, although patients treated with statins did not show higher survival rates. For other series of incident cases, there were differences in variables related to prognosis and mortality of patients.
Conclusions:
After an initial diagnosis of HF, more than half of patients die within 10 years of monitoring. Age, diabetes mellitus, ischemic heart disease and chronic renal failure are all associated with worse prognosis in these patients, whereas the use of beta-blockers and statins is associated with a better prognosis.
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