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Treatment Resistent Cancers02:56

Treatment Resistent Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...

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A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance
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Multimodality local therapy for retroperitoneal sarcoma.

Nitesh N Paryani1, Robert A Zlotecki, Erika L Swanson

  • 1Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, FL, USA.

International Journal of Radiation Oncology, Biology, Physics
|June 14, 2011
PubMed
Summary
This summary is machine-generated.

Achieving local control for retroperitoneal sarcoma is challenging. Complete surgical resection with negative margins is crucial for improving survival in patients treated with multimodality therapy.

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Area of Science:

  • Oncology
  • Surgical Oncology
  • Radiation Oncology

Background:

  • Retroperitoneal sarcomas are rare, often large tumors.
  • Surgery is the primary treatment, but achieving wide margins is difficult.
  • The role of radiotherapy in managing these tumors is debated.

Purpose of the Study:

  • To evaluate the institutional experience with multimodality local therapy for resectable retroperitoneal sarcoma.
  • To identify prognostic factors influencing disease control and survival.
  • To update data on combined surgery and radiation for retroperitoneal sarcoma.

Main Methods:

  • Retrospective analysis of 58 patients treated between 1974 and 2007.
  • Patients received either preoperative or postoperative radiotherapy.
  • Analysis of prognostic variables including margin status, grade, and radiotherapy sequencing.

Main Results:

  • 5-year survival and local control rates were 49% and 62%, respectively.
  • Local progression was a common cause of failure.
  • Negative margin status was the only significant predictor of improved local control and overall survival.

Conclusions:

  • Local control remains a significant challenge in retroperitoneal sarcoma management.
  • Combined-modality therapy can lead to substantial morbidity.
  • Improving local control is essential for enhancing patient survival.