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Related Experiment Video

Updated: Jun 1, 2026

Massive Pontine Hemorrhage by Dual Injection of Autologous Blood

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Published on: May 29, 2021

Massive transfusion protocols for patients with substantial hemorrhage.

Pampee P Young¹, Bryan A Cotton, Lawrence T Goodnough

¹Department of Pathology, Vanderbilt University School of Medicine, 1161 21st Ave South, C2217A MCN, Nashville, TN 37232, USA. pampee.young@vanderbilt.edu

Transfusion Medicine Reviews

|June 14, 2011

Summary

Massive transfusion protocols (MTPs) standardize hemorrhage resuscitation, improving blood product use and patient outcomes. This review examines MTP experiences and their value in academic transfusion services.

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Area of Science:

Transfusion Medicine
Emergency Medicine
Trauma Surgery

Background:

Massive hemorrhage resuscitation has evolved from reactive treatments to standardized Massive Transfusion Protocols (MTPs).
MTPs aim to standardize effective posthemorrhage treatments, enabling rapid execution and reducing blood product waste.
Damage control resuscitation is a key MTP strategy involving permissive hypotension and balanced blood product ratios.

Purpose of the Study:

To review published experiences with various Massive Transfusion Protocols (MTPs).
To illustrate the potential value of MTPs employed by academic transfusion services.
To discuss the ongoing controversy surrounding MTP implementation.

Main Methods:

Literature review of published experiences with MTPs.
Analysis of MTP strategies, including Damage Control Resuscitation.
Examination of blood product utilization and patient outcomes associated with MTPs.

Main Results:

MTPs standardize resuscitation, improving timely availability of blood components.
Damage control resuscitation employs permissive hypotension and balanced plasma, platelets, and red blood cells.
MTPs show potential value in managing massive hemorrhage patients.

Conclusions:

Standardized MTPs represent an advancement in massive hemorrhage resuscitation.
The timely and balanced administration of blood products via MTPs is crucial.
Further evaluation of MTPs in academic settings is warranted despite ongoing debate.