Related Experiment Video
Updated: Jun 1, 2026

Dual Electrophysiological Recordings of Synaptically-evoked Astroglial and Neuronal Responses in Acute Hippocampal Slices
Published on: November 26, 2012
Substantial changes in synaptic firing frequencies induced by glial ATP hysteresis
1IWR, University of Heidelberg, Im Neuenheimer Feld 294, Heidelberg, Germany. noori@math.uni-heidelberg.de
Abstract:
Recent experimental studies strongly suggest the influence of glial purinergic transmission in the modulation of synaptic dynamics. By releasing adenosine triphosphate (ATP), which accumulates as adenosine, astrocytes tonically suppressed synaptic transmission. The delayed multi-step feedback of the glial ATP with the neuron suggests the existence of a discrete hysteresis phenomena. By integration of this hysteretic behavior into a delayed leaky integrate-and-fire model for the tripartite synapses, a significant sensitivity of the pre- and postsynaptic firing frequency patterns to the adenosine feedback-delays is observed that might be of importance for adenosine-related neurological deficits, such as sleep disorders.
More Related Videos
Related Concept Videos
Integration of Synaptic Events
Long-term Potentiation
Hebbian LTP
LTP can occur when presynaptic neurons...
Long-term Potentiation
Excitatory and Inhibitory Effects of Neurotransmitters
Postsynaptic Potential (PSP)
There are two types of receptors: ionotropic and metabotropic.
The ionotropic receptor is the membrane protein that has an...
Ligand-Gated Ion Channel Receptor: Gating Mechanism

