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Steroid receptor coactivators 1, 2, and 3: critical regulators of nuclear receptor activity and steroid receptor

Amber B Johnson1, Bert W O'Malley

  • 1Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, United States.

Molecular and Cellular Endocrinology
|June 14, 2011
PubMed

Insights

Steroid receptor coactivators (SRCs) are key proteins in nuclear receptor (NR) function and are implicated in cancer. Targeting SRCs may offer new treatments for endocrine-resistant cancers.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Endocrinology

Background:

  • Coactivators are non-DNA binding proteins crucial for nuclear receptor (NR)-mediated transcription.
  • Steroid receptor coactivators (SRCs), including SRC-1, SRC-2, and SRC-3, are extensively studied for their roles in NR function.
  • SRCs are implicated in various diseases, particularly cancers like breast cancer.

Purpose of the Study:

  • To review the literature on SRCs, focusing on their oncogenic activity and potential as diagnostic/prognostic indicators.
  • To explore the role of SRCs in regulating interactions between selective receptor modulators (SRMs) and NRs.
  • To discuss the influence of SRCs on the functional outcomes of SRMs.

Main Methods:

  • Literature review of studies on SRCs, nuclear receptors, and selective receptor modulators.
  • Analysis of research supporting the oncogenic roles of SRCs.
  • Examination of the impact of SRCs on SRM-NR interactions and functional output.

Main Results:

  • SRCs are implicated in the oncogenic activity of NRs, especially in breast cancer.
  • SRCs influence the efficacy and functional output of selective receptor modulators (SRMs).
  • The literature supports the potential of SRCs as diagnostic and prognostic markers in cancer.

Conclusions:

  • SRCs play a significant role in NR-mediated transcriptional activation and disease, particularly cancer.
  • Understanding SRC-NR-SRM interactions is vital for developing targeted cancer therapies.
  • Coactivator-specific inhibitors represent a promising therapeutic strategy for endocrine-resistant cancers.

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