Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Local Anesthetics: Clinical Application as Epidural Anesthesia01:29

Local Anesthetics: Clinical Application as Epidural Anesthesia

Epidural anesthetics are administered in the fat-filled epidural space, the outermost part of the spinal canal. This technique is commonly employed for pain management and anesthesia during lower abdomen and pelvis surgeries or labor and delivery.
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Socio-behavioral factors linked to willingness to use new male contraceptives: A cross-sectional survey of men and female partners across four low- and middle-income countries.

Contraceptionยท2026
Same author

Examining the association between prior medical mistreatment and interest in and support for over-the-counter medication abortion among people seeking in-person abortion in the United States.

BMC health services researchยท2026
Same author

Accuracy of Self-Selection for Medication Abortion Using a Prototype Drug Facts Label.

JAMA internal medicineยท2026
Same author

Development of a consumer information leaflet for a prototype over-the-counter mifepristone and misoprostol medication abortion product.

Contraceptionยท2026
Same author

Letter to the editor: global availability of mifepristone for medical abortion and ulipristal acetate for emergency contraception.

The European journal of contraception & reproductive health care : the official journal of the European Society of Contraceptionยท2025
Same author

Trajectories of contraception before pregnancy and after medication abortion among women accessing clinic vs pharmacy services in Ghana.

Sexual & reproductive healthcare : official journal of the Swedish Association of Midwivesยท2025

Related Experiment Video

Updated: Jun 1, 2026

Auricular Point Acupressure Therapy: A Safe and Effective Treatment for Postsurgical Abortion Recovery
07:28

Auricular Point Acupressure Therapy: A Safe and Effective Treatment for Postsurgical Abortion Recovery

Published on: February 3, 2026

Clinical guidelines. Labor induction abortion in the second trimester.

Lynn Borgatta1, Nathalie Kapp,

  • 1Society of Family Planning

Contraception
|June 14, 2011
PubMed
Summary

The combination of mifepristone and misoprostol is the most effective regimen for second-trimester labor induction abortion, significantly reducing abortion time. When mifepristone is unavailable, misoprostol alone is a recommended alternative for effective abortion induction.

More Related Videos

External Cephalic Version: Is it an Effective and Safe Procedure?
08:49

External Cephalic Version: Is it an Effective and Safe Procedure?

Published on: June 6, 2020

Related Experiment Videos

Last Updated: Jun 1, 2026

Auricular Point Acupressure Therapy: A Safe and Effective Treatment for Postsurgical Abortion Recovery
07:28

Auricular Point Acupressure Therapy: A Safe and Effective Treatment for Postsurgical Abortion Recovery

Published on: February 3, 2026

External Cephalic Version: Is it an Effective and Safe Procedure?
08:49

External Cephalic Version: Is it an Effective and Safe Procedure?

Published on: June 6, 2020

Area of Science:

  • Reproductive Health
  • Pharmacology
  • Obstetrics

Background:

  • Labor induction abortion is a common procedure throughout the second trimester.
  • Gestational age and local practices influence abortion methods and timelines.
  • Complication rates in the second trimester have not been clearly linked to gestational age.

Purpose of the Study:

  • To evaluate the effectiveness and timing of different regimens for second-trimester labor induction abortion.
  • To compare the combination of mifepristone and misoprostol with other agents.
  • To provide evidence-based recommendations for optimal second-trimester abortion induction.

Main Methods:

  • Review of existing evidence on labor induction abortion regimens.
  • Comparison of time to abortion and complication rates for various drug combinations.
  • Analysis of factors influencing regimen choice, including drug availability and cost.

Main Results:

  • The combination of mifepristone and misoprostol is the fastest and most effective regimen, reducing abortion time by 40-50% compared to misoprostol alone.
  • Misoprostol alone, particularly when administered vaginally or sublingually in doses of 400 mcg every 3 hours, achieves abortion in 80-85% of cases within 24 hours.
  • Alternative agents like gemeprost and high-dose oxytocin are less preferred due to cost, storage, or specific contraindications.

Conclusions:

  • Mifepristone and misoprostol combination is the ideal regimen for rapid and complete second-trimester abortion induction.
  • Misoprostol alone is a viable alternative when mifepristone is inaccessible, with specific dosing and administration routes recommended for efficacy.
  • Further research is needed on the role of osmotic dilators and preprocedure fetal demise in second-trimester abortion induction.