Related Experiment Video
Updated: Jun 1, 2026

11:06
Identifying DNA Mutations in Purified Hematopoietic Stem/Progenitor Cells
Published on: February 24, 2014
Genetic lotteries within families
Jason M Fletcher1, Steven F Lehrer
1Yale University, School of Public Health, 60 College Street, #303, New Haven, CT 06520, USA. jason.fletcher@yale.edu
Journal of Health Economics
|June 14, 2011
Summary
Genetic differences between siblings can test economic models and reveal health impacts on education. This approach improves understanding of family economic relationships and health-education links.
Area of Science:
- Economics
- Genetics
- Health Outcomes
Background:
- Traditional within-family estimators may not fully address health endogeneity in education production functions.
- Understanding the causal impact of poor health on academic outcomes requires advanced econometric methods.
- Biomedical literature suggests genetic variations can be leveraged for economic analysis.
Purpose of the Study:
- To introduce the use of exogenously inherited genetic differences between siblings for testing within-family estimators.
- To improve the understanding of economic relationships by accounting for genetic and health factors.
- To causally identify the impact of poor health conditions on academic outcomes.
Main Methods:
- Utilizing differences in exogenously inherited genetic code between full biological siblings.
- Applying family fixed effects estimators in the context of education production functions.
- Employing genetic markers as instrumental variables for specific health conditions.
Main Results:
- Family fixed effects estimators alone are insufficient to fully control for health endogeneity.
- Exogenously inherited genetic differences offer a novel approach to within-family estimation.
- Genetic markers can effectively serve as instrumental variables for health conditions in this context.
Conclusions:
- Genetic variations between siblings provide a valuable tool for causal inference in economic studies.
- This methodology enhances the ability to disentangle the effects of health on education.
- The study offers improved methods for analyzing economic relationships influenced by health and genetics.
Related Concept Videos
Genetic Variation
Genetic variation is the diversity in DNA sequences found among individuals of the same species. This diversity is crucial for a species' survival because it helps organisms adapt to environmental changes. Genetic variation begins with fertilization, where an egg and sperm cell merge. Each of these cells carries 23 chromosomes, up to 46 in the fertilized egg. Chromosomes are long DNA strands that contain genes, the basic units of heredity.
Genes exist in different versions called alleles, which...
Genes exist in different versions called alleles, which...
Behavioral Genetics and Its Designs
Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
Law of Independent Assortment
While Mendel’s Law of Segregation states that the two alleles for one gene are separated into different gametes, a different question of how different genes are inherited remains. For example, is the gene for tall plants inherited with the gene for green peas? Mendel asked this question by experimenting with a dihybrid cross; a cross in which both parents are homozygous for two distinct traits resulting in an F1 generation that are heterozygous for both traits.
Law of Independent Assortment
While Mendel’s Law of Segregation states that the two alleles for one gene are separated into different gametes, a different question of how different genes are inherited remains. For example, is the gene for tall plants inherited with the gene for green peas? Mendel asked this question by experimenting with a dihybrid cross; a cross in which both parents are homozygous for two distinct traits resulting in an F1 generation that are heterozygous for both traits.
Genetic Screens
Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...
Punnett Squares
Overview

