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System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis
Published on: April 5, 2017
Synthesis and screening of galactose-linked nitroimidazoles and triazoles against Mycobacterium tuberculosis
G Mugunthan1, Kuppala Ramakrishna, Dharmarajan Sriram
1Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, SAS Nagar, Punjab 160062, India.
European Journal of Medicinal Chemistry
|June 14, 2011
Abstract:
A series of galactose-linked nitroimidazoles/triazoles were synthesised and screened against Mycobacterium tuberculosis H(37)Rv. Preliminary results were promising with MIC values in the range 1.56-12.5 μg/mL. Most importantly they are active under aerobic condition under which metronidazole is inactive.
