Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hallucinogens and Psychedelics01:27

Hallucinogens and Psychedelics

Hallucinogens are psychoactive substances that profoundly alter perceptual experiences, generating unreal visual and sensory images. Often referred to as psychedelic drugs — a term derived from the Greek words "psyche" (mind) and "delos" (revealing) — these substances include marijuana and lysergic acid diethylamide (LSD), among others. These drugs vary in intensity and effects.
Marijuana, derived from the dried leaves and flowers of the hemp plant, contains delta-9-tetrahydrocannabinol (THC)...
Role of Amygdala in Memory01:16

Role of Amygdala in Memory

The amygdala is a small, almond-shaped structure responsible for processing and storing memories, particularly those linked to emotions like fear and stress. It plays an essential role in the brain's response to emotionally significant events and often enhances memory formation by triggering stress hormone release. The amygdala is vital for encoding and retrieving memories associated with fear or stress, a process that is adaptive by helping organisms avoid dangerous situations.
One of the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Contributions of genetic liability and the COVID-19 pandemic to rising psychopathology among youth in the United States.

Translational psychiatry·2026
Same author

Multivariate associations between sleep patterns and self-regulation in adolescence: Canonical correlation analysis across ABCD and NCANDA cohorts.

Chronobiology international·2026
Same author

Developmental variation in basal ganglia tissue iron, neurocognitive functioning, and impulsivity is associated with substance use trajectories in youth.

Nature communications·2026
Same author

Predictors of Follow-Up Engagement in an Adolescent Alcohol Longitudinal Cohort.

Journal of studies on alcohol and drugs·2026
Same author

Social Media Usage and Its Association With the Social Media Addiction Questionnaire Scale Among Early Adolescents.

JAACAP open·2026
Same author

Illuminating posterior targets for TMS beyond the prefrontal cortex.

Nature. Mental health·2026

Related Experiment Video

Updated: Jun 1, 2026

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study
07:30

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Published on: August 18, 2020

Gender effects on amygdala morphometry in adolescent marijuana users.

Tim McQueeny1, Claudia B Padula, Jenessa Price

  • 1Department of Psychology, University of Cincinnati, Cincinnati, OH 45221, USA.

Behavioural Brain Research
|June 14, 2011
PubMed
Summary

Teenage girls using marijuana showed larger amygdala volumes and more internalizing symptoms, suggesting potential links between cannabis use and adolescent brain development, particularly in females.

More Related Videos

Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice
07:51

Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice

Published on: August 1, 2025

Social Defeat Stress Model for Adolescent C57BL/6 Male and Female Mice
07:15

Social Defeat Stress Model for Adolescent C57BL/6 Male and Female Mice

Published on: March 15, 2024

Related Experiment Videos

Last Updated: Jun 1, 2026

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study
07:30

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Published on: August 18, 2020

Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice
07:51

Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice

Published on: August 1, 2025

Social Defeat Stress Model for Adolescent C57BL/6 Male and Female Mice
07:15

Social Defeat Stress Model for Adolescent C57BL/6 Male and Female Mice

Published on: March 15, 2024

Area of Science:

  • Neuroscience
  • Adolescent Psychology
  • Substance Use Research

Background:

  • Adolescent brain development, particularly in the limbic system and endogenous cannabinoid system, may increase vulnerability to marijuana's negative effects.
  • Research suggests potential links between chronic marijuana use and alterations in brain structure and internalizing symptoms during teenage years.

Purpose of the Study:

  • To investigate the relationship between amygdala volume and internalizing symptoms in adolescent chronic marijuana users.
  • To explore potential gender differences in these relationships.

Main Methods:

  • Magnetic resonance imaging (MRI) was used to manually trace amygdala and intracranial volumes in 35 marijuana users and 47 controls (ages 16-19).
  • Participants underwent 28 days of monitored abstinence before assessments of substance use, internalizing symptoms (anxiety/depression), and brain scans.
  • Statistical analyses controlled for head size, alcohol, nicotine, and other substance use.

Main Results:

  • Female marijuana users exhibited larger right amygdala volumes and reported more internalizing symptoms compared to female controls.
  • Male marijuana users did not show significant differences in amygdala volume compared to male controls.
  • In female controls and males, worse mood/anxiety correlated with smaller right amygdala volume, while in female marijuana users, more internalizing problems were linked to larger right amygdala volume.

Conclusions:

  • Gender-specific interactions suggest marijuana may disrupt sex-specific neuromaturational processes in adolescents.
  • Subtle amygdala abnormalities might underlie heightened vulnerability to sub-diagnostic depression and anxiety in teenage female marijuana users.
  • Findings highlight the need for further research into the neurodevelopmental impact of adolescent cannabis exposure.