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Related Concept Videos

Role of Skin in Vitamin D Synthesis01:23

Role of Skin in Vitamin D Synthesis

The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin D3(cholecalciferol).
Development of Immunocompetence01:22

Development of Immunocompetence

The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...

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Vitamin D in fetal brain development.

Darryl Eyles1, Thomas Burne, John McGrath

  • 1Queensland Centre for Mental Health Research, The Park Centre for Mental Health, Wacol, QLD, Australia. eyles@uq.edu.au

Seminars in Cell & Developmental Biology
|June 14, 2011
PubMed
Summary
This summary is machine-generated.

This review summarizes how vitamin D influences brain development, impacting cell functions like differentiation and neurotrophic factor expression. Vitamin D deficiency in early life may lead to adverse neuropsychiatric outcomes.

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Nutritional Science

Background:

  • Vitamin D is recognized for its diverse cellular functions.
  • Emerging evidence highlights vitamin D's role in the developing central nervous system (CNS).
  • Potential impacts span cell differentiation, neurotrophic factors, and neurotransmitter synthesis.

Purpose of the Study:

  • To review the evidence linking vitamin D to brain development.
  • To explore specific mechanisms by which vitamin D affects the developing brain.
  • To discuss the implications of vitamin D deficiency in early life.

Main Methods:

  • Review of scientific literature on vitamin D and brain development.
  • Focus on experimental models examining in utero vitamin D deficiency.
  • Analysis of epidemiological data on vitamin D status and neuropsychiatric outcomes.

Main Results:

  • Vitamin D influences multiple neurodevelopmental processes, including cell differentiation and gene expression.
  • Experimental models demonstrate adverse effects of dietary vitamin D absence during development.
  • Epidemiological studies suggest a correlation between early-life vitamin D deficiency and neuropsychiatric issues.

Conclusions:

  • Vitamin D plays a critical role in normal brain development.
  • Disruptions in vitamin D-dependent processes can negatively impact neurodevelopment.
  • Further research and attention to vitamin D status are warranted for optimal brain health.