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Updated: Jun 1, 2026

Anti-Nuclear Antibody Screening Using HEp-2 Cells

Anti-Nuclear Antibody Screening Using HEp-2 Cells

Published on: June 23, 2014

Seronegative spondyloarthritis.

Jane Zochling¹, Emma U R Smith

¹Menzies Research Institute, Hobart, Australia. Jane.Zochling@utas.edu.au

Best Practice & Research. Clinical Rheumatology

|June 14, 2011

Summary

Seronegative spondyloarthritis (SpA) encompasses inflammatory rheumatic diseases like ankylosing spondylitis and psoriatic arthritis. These conditions share features such as arthritis and enthesitis, often linked to HLA-B27.

Area of Science:

Rheumatology
Immunology
Genetics

Background:

Seronegative spondyloarthritis (SpA) comprises a group of inflammatory rheumatic diseases.
Common features include axial and peripheral arthritis, enthesitis, and extra-articular manifestations.
A strong association exists with the human leucocyte antigen (HLA)-B27 epitope.

Purpose of the Study:

To summarize the epidemiology and key characteristics of seronegative spondyloarthritis.
To highlight the prevalence and incidence of major SpA subtypes.
To underscore the clinical and etiological links within the SpA spectrum.

Main Methods:

Literature review and synthesis of epidemiological data.
Analysis of prevalence and incidence rates for various SpA conditions.

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Identification of common clinical and etiological features.

Main Results:

Ankylosing spondylitis prevalence varies (0.15%-1.8% in Caucasians), influenced by HLA-B27 positivity.
Psoriatic arthritis prevalence ranges from 0.02% to 0.2% generally, rising to 6-42% in psoriasis patients.
Reactive arthritis incidence depends on infection rates, and SpA symptoms appear in up to 50% of inflammatory bowel disease patients.

Conclusions:

Seronegative spondyloarthritis represents a spectrum of related inflammatory diseases.
Prevalence and incidence vary significantly among subtypes and populations.
Understanding these epidemiological patterns is crucial for disease management and research.