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The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice
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Published on: November 1, 2015

Systemic lupus erythematosus.

Sean O'Neill1, Ricard Cervera

  • 1Department of Rheumatology, Liverpool Hospital, Sydney, Australia.

Best Practice & Research. Clinical Rheumatology
|June 14, 2011
PubMed
Summary
This summary is machine-generated.

Systemic lupus erythematosus (SLE) is a diverse autoimmune disease with varied manifestations. Global epidemiological studies reveal significant differences in SLE occurrence across demographics and locations, highlighting complex risk factors.

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Last Updated: Jun 1, 2026

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Area of Science:

  • Immunology
  • Epidemiology
  • Genetics

Background:

  • Systemic lupus erythematosus (SLE) is a complex autoimmune disease affecting multiple organs.
  • SLE exhibits diverse clinical and immunological presentations.
  • Prevalence and disease course vary significantly across gender, age, race, and geographic locations.

Purpose of the Study:

  • To review epidemiological findings on Systemic lupus erythematosus (SLE).
  • To explore disparities in SLE prevalence and risk factors globally.
  • To understand the influence of genetic and environmental factors on SLE etiology.

Main Methods:

  • Analysis of epidemiological data from international SLE cohorts.
  • Review of studies investigating environmental and genetic risk factors.
  • Comparative analysis of SLE occurrence across diverse populations.

Main Results:

  • Significant global variations in SLE prevalence and incidence are confirmed.
  • Demographic factors (gender, age, race) and geographic location strongly influence SLE risk.
  • Challenges remain in identifying specific infectious or environmental contributors due to multifactorial etiology and study limitations.

Conclusions:

  • SLE epidemiology is highly heterogeneous worldwide.
  • Further international collaborative efforts are crucial for clarifying SLE risks in various groups.
  • Understanding global SLE patterns is essential for targeted prevention and management strategies.