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Updated: Jun 1, 2026
14:57
Yeast As a Chassis for Developing Functional Assays to Study Human P53
Published on: August 4, 2019
Oncogene-induced mitotic stress: p53 and pRb get mad too
1Cell Division and Cancer Group, Spanish National Cancer Research Center (CNIO), Madrid, Spain. malumbres@cnio.es
Cancer Cell
|June 14, 2011
Abstract:
Oncogenic signaling frequently results in unscheduled overexpression of cell cycle proteins and replicative stress. In this issue of Cancer Cell, Schvartzman et al. show that inactivation of p53 or pRb induces Mad2, and the overexpression of this mitotic checkpoint protein is a necessary event during oncogene-induced mitotic stress.
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