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Neuronal influence on intestinal transport.

M Jodal1

  • 1Department of Physiology, University of Göteborg, Sweden.

Journal of Internal Medicine. Supplement
|January 1, 1990
PubMed
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Nerve reflexes originating in the gut trigger intestinal secretion. Blocking these nerves significantly inhibits secretion, revealing a coordinated neural pathway from receptor cells to effector cells in the intestine.

Area of Science:

  • Neurogastroenterology
  • Physiology
  • Cell Biology

Background:

  • The enteric nervous system (ENS) controls intestinal secretion through reflex pathways.
  • Various stimuli, including mechanical distention and toxins, activate these reflexes.

Purpose of the Study:

  • To elucidate the organization and neural pathways of secretory enteric nervous reflexes.
  • To identify the key components and neurotransmitters involved in reflex-induced intestinal secretion.

Main Methods:

  • In vitro and in vivo studies were conducted to investigate the reflex mechanisms.
  • Nerve-blocking agents were used to assess the role of neural pathways in intestinal secretion.

Main Results:

  • Reflex activation of the ENS from the intestinal lumen or serosa induces secretion.

Related Experiment Videos

  • Nerve-blocking agents inhibited secretion by 60-100%, confirming neural involvement.
  • A proposed pathway involves receptor cells (EC, N-cells) releasing peptides/amines, activating afferent neurons via tachykinins to the myenteric plexus, then to submucosal plexus and efferent neurons using cholinergic nicotinic receptors.

    • Conclusions:

    • The myenteric plexus plays a superior and coordinating role in ENS control of intestinal function.
    • Acetylcholine and VIP are identified as key transmitters at effector cells in secretory reflexes.