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Detection of Invasive Pulmonary Aspergillosis in Haematological Malignancy Patients by using Lateral-flow Technology
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Published on: March 22, 2012

Invasive aspergillosis of orbit in immunocompetent patients: treatment and outcome

Neelam Pushker1, Rachna Meel, Seema Kashyap

  • 1Oculoplastics and Orbit Services, Dr. Rajendra Prasad Center for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

Ophthalmology
|June 14, 2011
PubMed
Abstract

Insights

Invasive sino-orbital aspergillosis in immunocompetent individuals can be effectively treated with newer antifungal agents, often avoiding surgery. This study highlights successful outcomes in 15 cases, emphasizing timely medical intervention for this rare condition.

Area of Science:

  • Ophthalmology
  • Infectious Diseases
  • Mycology

Background:

  • Invasive sino-orbital aspergillosis is a rare and potentially fatal fungal infection.
  • It frequently occurs in immunocompetent individuals and is often misdiagnosed.
  • There are currently no established universal treatment guidelines.

Observation:

  • This study presents a retrospective case series of 15 immunocompetent patients diagnosed with sino-orbital/orbital aspergillosis.
  • Diagnosis was confirmed via histopathology, identifying fungal hyphae and granulomatous inflammation.
  • Patients were treated between 1999 and 2009.

Findings:

  • Eleven of the 14 treated patients survived without recurrence at a median follow-up of 20 months.
  • Medical therapy included amphotericin B, itraconazole, and voriconazole, with newer agents showing promise.
  • Surgery was performed in 6 patients, but its role remains unclear; 5 patients had residual masses post-treatment.

Implications:

  • Newer antifungal agents appear effective in controlling sino-orbital aspergillosis in immunocompetent patients.
  • The necessity and role of surgical intervention require further investigation.
  • Timely medical treatment is crucial for improving survival rates in this rare infection.

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