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Related Concept Videos

Depressive Disorders: Etiology01:27

Depressive Disorders: Etiology

Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
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Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Long-term Depression01:03

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Related Experiment Video

Updated: Jun 1, 2026

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents
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Chronic prostatitis and depressive disorder: a three year population-based study.

Shiu-Dong Chung1, Chung-Chien Huang, Herng-Ching Lin

  • 1Division of Urology, Department of Surgery, Far Eastern Memorial Hospital, Ban Ciao, Taipei, Taiwan.

Journal of Affective Disorders
|June 14, 2011
PubMed
Summary
This summary is machine-generated.

Chronic prostatitis (CP) patients have a significantly higher risk of developing depressive disorders (DD) within three years. This risk is particularly pronounced in younger men under 30.

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Area of Science:

  • Urology
  • Psychiatry
  • Epidemiology

Background:

  • Limited research exists on the link between chronic prostatitis (CP) and depressive disorders (DD).
  • Population-based studies are needed to investigate this association prospectively.

Purpose of the Study:

  • To examine the relationship between a history of chronic prostatitis (CP) and the subsequent risk of developing depressive disorders (DD).

Main Methods:

  • A prospective cohort study involving 3051 adult patients diagnosed with CP and 15,255 matched controls.
  • Patients were tracked for three years to identify new diagnoses of DD.
  • Cox proportional hazards models were used to analyze the risk of DD, adjusting for socio-demographic factors.

Main Results:

  • Patients with CP had a 1.63 times higher risk of developing DD compared to controls (95% CI = 1.36-1.96).
  • The risk was substantially higher in younger patients, particularly those under 30 (HR = 2.50, 95% CI = 1.18-4.51).
  • The prevalence of DD was 5.34% in the CP group versus 3.24% in the control group.

Conclusions:

  • Chronic prostatitis is associated with an increased risk of depressive disorders.
  • This association warrants further investigation and consideration in clinical practice.