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Updated: Jun 1, 2026
06:38
A Novel Method for the Culture and Polarized Stimulation of Human Intestinal Mucosa Explants
Published on: May 1, 2013
Recombinant lactic acid bacteria as mucosal biotherapeutic agents
Catherine Daniel1, Yvonne Roussel, Michiel Kleerebezem
1Institut Pasteur de Lille, Center for Infection and Immunity of Lille, Université Lille Nord de France, CNRS, UMR 8204, Institut National de la Santé et de la Recherche Médicale, U1019, F-59019 Lille, France. catherine.daniel@ibl.fr
Trends in Biotechnology
|June 14, 2011
Summary
Recombinant lactic acid bacteria (LAB) show promise for delivering therapeutic proteins safely in the gastrointestinal tract. Recent human trials highlight their potential for effective use in human health applications.
Area of Science:
- Microbiology
- Biotechnology
- Gastroenterology
Background:
- Lactic acid bacteria (LAB) are safe and can survive the gastrointestinal (GI) tract.
- Recombinant LAB have demonstrated health benefits when administered mucosally, primarily in animal models.
- The field is advancing into human clinical trials for therapeutic applications.
Purpose of the Study:
- To provide an update on recent advances in recombinant LAB technology.
- To outline the potential of recombinant LAB as therapeutic tools.
- To discuss the safe and efficient use of recombinant LAB in human health.
Main Methods:
- Review of recent scientific literature on recombinant LAB.
- Analysis of data from animal models and human clinical trials.
- Assessment of safety and efficacy of LAB-based therapies.
Main Results:
- Significant progress has been made in developing recombinant LAB for therapeutic protein production and delivery.
- Successful demonstrations of health benefits in animal models.
- Transition of research into human clinical trials.
Conclusions:
- Recombinant LAB are viable candidates for in situ production and delivery of therapeutic proteins.
- The safety and efficacy of recombinant LAB in human health are increasingly evident.
- Recombinant LAB hold significant potential as safe and efficient therapeutic tools.
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