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Related Concept Videos

Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Preparation and Reactions of Sulfides02:26

Preparation and Reactions of Sulfides

Sulfides are the sulfur analog of ethers, just as thiols are the sulfur analog of alcohol. Like ethers, sulfides also consist of two hydrocarbon groups bonded to the central sulfur atom. Depending upon the type of groups present, sulfides can be symmetrical or asymmetrical. Symmetrical sulfides can be prepared via an SN2 reaction between 2 equivalents of an alkyl halide and one equivalent of sodium sulfide.
Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Asthma III: Clinical Manifestations01:13

Asthma III: Clinical Manifestations

Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...

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Updated: Jun 1, 2026

A Sensitive Visual Method for the Detection of Hydrogen Sulfide Producing Bacteria
03:55

A Sensitive Visual Method for the Detection of Hydrogen Sulfide Producing Bacteria

Published on: June 27, 2022

Hydrogen sulfide and asthma.

Peipei Wang1, Gensheng Zhang, Taddese Wondimu

  • 1Department of Biology, Lakehead University, Thunder Bay, Ontario, Canada P7B 5E1.

Experimental Physiology
|June 14, 2011
PubMed
Summary
This summary is machine-generated.

Reduced hydrogen sulfide (H2S) levels are linked to asthma severity. Supplementing with H2S may offer a new therapeutic approach for asthma and H2S may serve as an early detection biomarker.

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Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device
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Measurement of H2S in Crude Oil and Crude Oil Headspace Using Multidimensional Gas Chromatography, Deans Switching and Sulfur-selective Detection
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Published on: September 24, 2020

Area of Science:

  • Pulmonary Medicine
  • Biochemistry

Background:

  • Asthma is a chronic airway inflammatory disease characterized by hyper-responsiveness and remodeling.
  • Endogenous hydrogen sulfide (H2S) plays a role in regulating airway inflammation and responsiveness.
  • H2S is produced by cystathionine β-synthase (CBS) and cystathionine γ-lyase (CSE) in lung and airway tissues.

Purpose of the Study:

  • To investigate the role of endogenous hydrogen sulfide (H2S) in asthma pathogenesis.
  • To evaluate H2S as a potential biomarker for early asthma detection.
  • To explore H2S-based therapeutic strategies for asthma.

Main Methods:

  • Review of studies on H2S metabolism and function in asthma models and patients.
  • Analysis of H2S-generating enzyme expression (CBS and CSE) in airway tissues.
  • Assessment of exogenous H2S supplementation effects in experimental asthma.

Main Results:

  • Abnormal H2S metabolism and function are observed in experimental asthma models.
  • Asthma patients exhibit significantly reduced serum H2S levels.
  • Exogenous H2S administration mitigates asthma severity in animal studies.

Conclusions:

  • Decreased H2S production may serve as an early diagnostic biomarker for asthma.
  • H2S-based therapy presents a promising new treatment strategy for asthma.
  • Further research is needed to understand H2S mechanisms and diagnostic/therapeutic applications.