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Related Experiment Video

Updated: Jun 1, 2026

Reproductive Techniques for Ovarian Monitoring and Control in Amphibians

Reproductive Techniques for Ovarian Monitoring and Control in Amphibians

Published on: May 12, 2019

Ulipristal acetate for emergency contraception.

Sara E Snow¹, Stephanie N Melillo, Courtney I Jarvis

¹Biogen Idec/Massachusetts College of Pharmacy and Health Sciences, School of Pharmacy, Worcester, Manchester, MA, USA. sarasnow23@gmail.com

The Annals of Pharmacotherapy

|June 14, 2011

Summary

Ulipristal acetate is an effective emergency contraceptive, usable up to 120 hours after unprotected intercourse. This progesterone agonist/antagonist demonstrates comparable efficacy to levonorgestrel in preventing pregnancy.

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Area of Science:

Reproductive Health
Pharmacology
Contraception

Background:

Ulipristal acetate is a novel emergency contraceptive.
It is approved for use within 120 hours of unprotected intercourse.

Purpose of the Study:

To review the pharmacology, pharmacokinetics, efficacy, and safety of ulipristal acetate.
To assess its role as an emergency contraceptive.

Main Methods:

Literature search of PubMed and clinicaltrials.gov.
Review of FDA approval documents.
Evaluation of 3 randomized trials and 1 meta-analysis.

Main Results:

Ulipristal acetate is a progesterone agonist/antagonist.
It is at least as effective as levonorgestrel in preventing pregnancy up to 120 hours post-intercourse.
Common side effects include headache, breast tenderness, nausea, and abdominal pain.

Conclusions:

Ulipristal acetate is an effective emergency contraceptive option for up to 120 hours after unprotected intercourse.
Prescription access and associated costs (appointment, travel) are considerations.
Its mechanism of action, similar to mifepristone, has generated discussion.