Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Distance Measurements by Taping

Distance Measurements by Taping

Tapes are essential in surveying for accurate, durable, and short-distance measurements. Made from lightweight, nylon-coated steel, they offer flexibility and strength for rugged outdoor use. The nylon coating protects against rust and wear, extending the tape's life. Standard lengths, around 30 meters, are marked in meters and millimeters for precision.Surveyors select tapes based on site conditions and accuracy needs. Lightweight, nylon-coated tapes are commonly used for ease of handling and...

Crossover Experiments

Crossover Experiments

Crossover experiments, also called the repeated-measurements design, is a study design in which all experimental units are exposed to all treatments in different periods. Crossover experiments are generally used in psychology, the pharmaceutical industry, agriculture, and medicine.
Crossover designs are performed even with smaller sample sizes since the samples can act as their controls. These are better than simple randomized trials since patients are exposed to all the treatments.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Variants in human CD48 lead to impaired T cell immunity and increased inflammation.

The Journal of clinical investigation·2026

Same author

Unlocking the undruggable spliceosome: generative AI and structural dynamics in cancer therapy.

Frontiers in cell and developmental biology·2026

Same author

Editorial: Precision oncology in checkpoint immunotherapy: leveraging predictive biomarkers for personalized treatment.

Frontiers in immunology·2026

Same author

Impact of clinical experience on the use of contralateral comparison radiographs in pediatric elbow and ankle trauma: a multicenter observer study.

Journal of pediatric orthopedics. Part B·2026

Same author

Retrospective analysis of subclavian venous catheterization procedures performed with ultrasound guidance by anesthesiology residents in the intensive care unit.

Frontiers in medicine·2025

Same author

Is Shoulder Impingement One of the Reasons for Elastofibroma Dorsi ? Radiological and Clinical Analysis of 13 Patients.

Indian journal of orthopaedics·2025

Same journal

3DICE: Interpretable 3D Cross-Modal Learning for Drug-Target Interaction Prediction and Large-Scale Drug Discovery.

Bioinformatics (Oxford, England)·2026

Same journal

KASSPer: Kinase Active Site Structure Prediction using Protein and Ligand Language Models and Its Application to Virtual Screening.

Bioinformatics (Oxford, England)·2026

Same journal

IDR searcher: a search engine solution for public image resources.

Bioinformatics (Oxford, England)·2026

Same journal

KCFtools: Rapid alignment-free method for introgression screening and GWAS using k-mer profiles.

Bioinformatics (Oxford, England)·2026

Same journal

Meta2DB: Curated shotgun metagenomic feature sets and metadata for health state prediction.

Bioinformatics (Oxford, England)·2026

Same journal

conMItion: an R package adjusting confounding factors for associations in multi-omics.

Bioinformatics (Oxford, England)·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 1, 2026

Robust 3D DNA FISH Using Directly Labeled Probes

Robust 3D DNA FISH Using Directly Labeled Probes

Published on: August 15, 2013

Xwalk: computing and visualizing distances in cross-linking experiments.

Abdullah Kahraman¹, Lars Malmström, Ruedi Aebersold

¹Department of Biology, Institute of Molecular Systems Biology, Swiss Federal Institute of Technology (ETH Zurich), CH-8093 Zurich, Switzerland. abdullah@imsb.biol.ethz.ch

Bioinformatics (Oxford, England)

|June 14, 2011

Summary

This summary is machine-generated.

We developed Xwalk, an algorithm that predicts and validates chemical cross-links on protein structures. Xwalk calculates solvent accessible surface distances, aiding in understanding protein topology and complex interactions.

More Related Videos

Simultaneous Visualization of the Dynamics of Crosslinked and Single Microtubules In Vitro by TIRF Microscopy

Simultaneous Visualization of the Dynamics of Crosslinked and Single Microtubules In Vitro by TIRF Microscopy

Published on: February 18, 2022

Combined Immunofluorescence and DNA FISH on 3D-preserved Interphase Nuclei to Study Changes in 3D Nuclear Organization

Combined Immunofluorescence and DNA FISH on 3D-preserved Interphase Nuclei to Study Changes in 3D Nuclear Organization

Published on: February 3, 2013

Related Experiment Videos

Last Updated: Jun 1, 2026

Robust 3D DNA FISH Using Directly Labeled Probes

Robust 3D DNA FISH Using Directly Labeled Probes

Published on: August 15, 2013

Simultaneous Visualization of the Dynamics of Crosslinked and Single Microtubules In Vitro by TIRF Microscopy

Simultaneous Visualization of the Dynamics of Crosslinked and Single Microtubules In Vitro by TIRF Microscopy

Published on: February 18, 2022

Combined Immunofluorescence and DNA FISH on 3D-preserved Interphase Nuclei to Study Changes in 3D Nuclear Organization

Combined Immunofluorescence and DNA FISH on 3D-preserved Interphase Nuclei to Study Changes in 3D Nuclear Organization

Published on: February 3, 2013

Area of Science:

Structural biology
Computational biology
Biochemistry

Background:

Chemical cross-linking coupled with mass spectrometry provides distance restraints for protein topology.
Accurate localization of cross-linked amino acids is crucial for structural analysis.

Purpose of the Study:

To introduce Xwalk, a novel algorithm for predicting and validating chemical cross-links on existing protein structures.
To provide a computational tool that mimics cross-linker flexibility and calculates biologically relevant distances.

Main Methods:

Developed the Xwalk algorithm for predicting and validating cross-links.
Implemented calculation of non-linear, solvent accessible surface distances between cross-linked amino acids.
Modeled flexibility and non-linearity of cross-linker molecules.

Main Results:

Xwalk accurately predicts and validates cross-links on protein structures.
The algorithm calculates solvent accessible surface distances, representing shortest paths through solvent.
Xwalk effectively mimics the biophysical properties of cross-linker molecules.

Conclusions:

Xwalk is a valuable tool for interpreting cross-linking mass spectrometry data.
The algorithm enhances the generation of distance restraints for protein structure determination.
Xwalk facilitates a deeper understanding of protein complex topology and dynamics.