[Stereological study of the goblet-cell in colon with special reference to carcinoma]

Contrast-study for goblet-cells of the intestinal mucosa, polypoid adenoma, villus adenoma, non-type epitheliosis and ductal adenoid carcinoma of colon was carried out via stereological analysis, including stereology measure of structure parameter and particle parameter of volume density(Vv), surface density(Sv) and number density(Nv). By means of coherent test system A100, spot count, intersection count and profile count method were applied in each group for goblet-cell counting. Data indicated that goblet-cell decreased corresponding to the lowering down of differentiation stage of epithelial cell in large intestine. Goblet-cell of nearly 50% of adenoid carcinoma disappeared completely. Indices of Vv less than 0.03, Sv less than 2.3mm-1, Nv less than 16.1mm-3 were considered as important criteria for the diagnosis of early carcinoma. Besides, non-type hyperplasia was obtained also in polypoid adenoma of colon. So, there is the possibility of undergoing malignant change.