The role of human papillomavirus on sperm function

Area of Science:

• Reproductive Medicine
• Virology
• Men's Health

Background:

• Human papillomavirus (HPV) is a common sexually transmitted infection linked to warts and cancers.
• HPV infection is frequently detected in semen of sexually active men, including those with infertility.

Purpose of the Study:

• To review the impact of human papillomavirus (HPV) on sperm parameters and fertility.
• To examine the implications of using HPV-infected sperm in assisted reproduction.

Main Methods:

• Literature review of recent studies on HPV infection in semen.
• Analysis of the effects of HPV on sperm function and reproductive outcomes.

Main Results:

• Semen infection with HPV is associated with impaired sperm parameters, suggesting a role in male infertility.
• HPV-infected sperm can penetrate oocytes, deliver viral DNA, and lead to active transcription.
• Pregnancy loss risk increases in couples undergoing IVF when male partners have HPV DNA in semen.

Conclusions:

• Current strategies for treating and preventing male HPV semen infection are lacking.
• Male HPV infection poses risks to partners and may contribute to infertility and early miscarriage.
• Increased attention and research are needed for male HPV infection and its reproductive consequences.