Related Experiment Video
Updated: Jun 1, 2026
18:48
In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
Published on: August 12, 2017
B-cell immunotherapeutics: emerging roles in solid organ transplantation
Stanley C Jordan1, Joseph Kahwaji, Mieko Toyoda
1Comprehensive Transplant Center, Kidney Transplant Program and Transplant Immunotherapy Program, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA. sjordan@cshs.org
Current Opinion in Organ Transplantation
|June 14, 2011
Summary
B-cell-directed therapies show promise for modifying alloimmunity in transplant recipients by targeting B cells and their functions. This review explores current and emerging treatments for B-cell modulation in transplantation.
Area of Science:
- Immunology
- Transplantation Science
Background:
- B cells play a critical role in autoimmunity and alloimmunity.
- B cells mediate effector functions including antibody production, antigen presentation, and cytokine release.
- Advances in understanding B cells impact solid organ transplantation, particularly for ABO incompatible or HLA-sensitized patients.
Purpose of the Study:
- To review current and evolving B-cell-directed therapies for autoimmune diseases.
- To discuss the potential of these therapies in modifying alloimmunity in transplant recipients.
- To define the critical role of B cells in alloimmunity and how B-cell-directed therapies can modify it.
Main Methods:
- Review of existing literature on B-cell-directed therapies.
- Focus on data from human and animal models targeting B cells and antibodies in transplantation.
- Inclusion of established therapies like intravenous immunoglobulin and anti-CD20 (rituximab).
Main Results:
- B-cell depletion and modulation agents are being developed for transplantation.
- Therapies targeting B cells and antibodies can reduce inflammation in transplantation.
- Emerging therapies include agents targeting B-cell activating factor, anti-CD22, and interleukin 6 receptor.
Conclusions:
- B cells are critical in the development of alloimmunity.
- B-cell-directed therapies offer a promising approach to modify alloimmunity in transplant recipients.
- Further research into these therapies is essential for improving transplant outcomes.
Related Concept Videos
01:40Cell-mediated Immune Responses
Overview
01:24Tissue Transplantation
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
01:22Bone Marrow Sampling and Transplants
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
01:27Tumor Immunotherapy
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
01:28Kidney Transplant I: Introduction
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
01:24B Cell Activation and Differentiation
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...