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Updated: Jun 1, 2026

Detecting Somatic Genetic Alterations in Tumor Specimens by Exon Capture and Massively Parallel Sequencing
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Published on: October 18, 2013

CREST maps somatic structural variation in cancer genomes with base-pair resolution

Jianmin Wang1, Charles G Mullighan, John Easton

  • 1Department of Information Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.

Nature Methods
|June 14, 2011
PubMed
Summary

We created a new algorithm called CREST to precisely map genetic structural variations using sequencing data. This tool accurately identified 160 new variations in leukemia and melanoma samples.

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