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Related Experiment Videos

Receptor-mediated calcium entry.

T J Rink1

  • 1Physiological Laboratory, Cambridge, UK.

FEBS Letters
|August 1, 1990
PubMed
Summary
This summary is machine-generated.

Membrane receptor activation triggers calcium signals. This review explores receptor-mediated calcium entry (RCME) pathways, including novel blockers and entry into intracellular stores bypassing the cytosol.

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Area of Science:

  • Cellular Biology
  • Physiology
  • Biochemistry

Background:

  • Membrane receptor occupation initiates calcium signals via depolarization, internal release, or receptor-mediated calcium entry (RCME).
  • RCME involves calcium influx not gated by membrane potential, crucial for cellular signaling.
  • Understanding RCME mechanisms is vital for comprehending cellular responses.

Purpose of the Study:

  • To review coupling mechanisms of receptor-mediated calcium entry (RCME).
  • To explore the novel concept of calcium entry into intracellular stores, bypassing the cytosol.
  • To present recent findings on RCME using Mn2+ probes, electrophysiology, and a novel blocker.

Main Methods:

  • Review of existing literature on calcium signaling and RCME.

Related Experiment Videos

  • Analysis of studies employing Mn2+ as a probe for RCME.
  • Electrophysiologic measurements in human platelets.
  • Investigation of the novel blocker SK&F 96365 for RCME.

    • Main Results:

    • Multiple coupling mechanisms for RCME are considered.
    • Evidence suggests calcium can enter intracellular stores directly, bypassing the cytosol, regulated by store-filling status.
    • New data from Mn2+ probes and human platelet electrophysiology are presented.
    • The novel blocker SK&F 96365 shows potential in modulating RCME.

    Conclusions:

    • Receptor-mediated calcium entry is a complex process with diverse mechanisms.
    • The direct entry of calcium into intracellular stores represents a significant new pathway.
    • Further research into RCME, its regulation, and modulators like SK&F 96365 is warranted.