Related Experiment Video
Updated: Jun 1, 2026

Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection
Published on: May 10, 2024
D-dimer as a marker of severity in patients with severe acute pancreatitis
Lu Ke1, Hai-Bin Ni, Zhi-Hui Tong
1Department of General Surgery, Jinling Hospital, Nanjing University School of Medicine, Nanjing 210002, China.
Background/Purpose:
Coagulative disorder is known to occur in the early phase of severe acute pancreatitis (SAP) and D: -dimer is a commonly used clinical parameter of hemostasis. The aim of this study was to assess the value of the plasma D: -dimer level as a marker of severity in the first 3 days after admission in patients with SAP.
Methods:
From January 2009 to February 2011, 45 patients admitted for SAP were included in this observational study. The D: -dimer level was measured on a daily basis during days 1-3 after admission and the acute physiology and chronic health evaluation (APACHE) II score, sequential organ failure assessment (SOFA) score, and other clinical parameters were recorded at the same time. The maximum and the mean D: -dimer values were used for analysis and compared with other prognostic factors of SAP.
Results:
Both the maximum and mean levels of D: -dimer were significantly different between patients with and without clinical variables such as multiple-organ dysfunction syndrome (MODS), need for surgical intervention, and the presence of pancreatic infection. The D: -dimer level also showed great precision for the prediction of MODS and secondary infection. Additionally, the D: -dimer level correlated well with two usual markers of SAP severity-the APACHE II score and the C-reactive protein level.
Conclusion:
D: -dimer measurement is a useful, easy, and inexpensive early prognostic marker of the evolution and complications of SAP.
Related Concept Videos
Acute Pancreatitis II: Clinical Manifestations and Management
Acute Pancreatitis I: Introduction
Acute Pancreatitis I: Introduction
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
Acute Pancreatitis II: Pathophysiology
Chronic Pancreatitis I: Introduction
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Chronic Pancreatitis I: Introduction

