Simulation and experimental studies on magnetic hyperthermia with use of superparamagnetic iron oxide nanoparticles

Our purpose of this study was to present simulation and experimental studies on magnetic hyperthermia (MH) with use of an alternating magnetic field (AMF) and superparamagnetic iron oxide nanoparticles (Resovist®). In the simulation studies, the energy dissipation (P) and temperature rise rate (∆T/∆t) were computed under various conditions by use of the probability density function of the particle size distribution based on a log-normal distribution. P and ∆T/∆t and their dependence on the frequency of the AMF (f) largely depended on the particle size of Resovist®. P and ∆T/∆t reached maximum at a diameter of ~24 nm, and were proportional to the amplitude of the AMF (H (0)) raised to a power of ~2.0. In the experimental studies, we made a device for generating an AMF, and measured the temperature rise under various concentrations of Resovist®, H (0), and f. The temperature rise at 10 min after the start of heating was linearly proportional to the concentration of Resovist®, and proportional to H (0) raised to a power of ~2.4, which was slightly greater than that expected from the simulation studies. There was a tendency for the temperature rise to saturate with increasing f. In conclusion, this study will be useful for investigating the feasibility of MH with Resovist® and optimizing the parameters for it.