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Updated: Jun 1, 2026

Contribution of the Na+/K+ Pump to Rhythmic Bursting, Explored with Modeling and Dynamic Clamp Analyses
Published on: May 9, 2021
A simple integrative electrophysiological model of bursting GnRH neurons
Dávid Csercsik1, Imre Farkas, Erik Hrabovszky
1Process Control Research Group, Computer and Automation Research Institute, Hungarian Academy of Sciences, P.O. Box 63, 1518 Budapest, Hungary. csercsik@scl.sztaki.hu
Abstract:
In this paper a modular model of the GnRH neuron is presented. For the aim of simplicity, the currents corresponding to fast time scales and action potential generation are described by an impulsive system, while the slower currents and calcium dynamics are described by usual ordinary differential equations (ODEs). The model is able to reproduce the depolarizing afterpotentials, afterhyperpolarization, periodic bursting behavior and the corresponding calcium transients observed in the case of GnRH neurons.
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