Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Less Is More: An Interprofessional Educational Activity on Safe and Effective Deprescribing.

The Journal of nursing education·2026
Same author

<i>"Put Me in, Coach"</i>: A Discussion of Deprescribing Roles, Responsibilities, and Motivations Based on a Qualitative Study with Healthcare Professional Students.

Pharmacy (Basel, Switzerland)·2025
Same author

Structural Bifurcation in the High→Low-Spin and Low→High-Spin Phase Transitions Explains the Asymmetric Spin-Crossover in [FeL<sub>2</sub>][BF<sub>4</sub>]<sub>2</sub> (L=2,6-Di{pyrazol-1-yl}isonicotinonitrile).

Angewandte Chemie (International ed. in English)·2024
Same author

"I think deprescribing is very needed in our society:" Healthcare Professional Students Perceptions of Deprescribing Education.

Innovations in pharmacy·2024
Same author

Inclusion in the clinic: A mixed methods study of left-handed student's perceptions of using cordless keyboards.

Journal of dental education·2024
Same author

"Locate the Law" activity: Evaluating student pharmacists' ability to locate and use legal resources.

American journal of pharmaceutical education·2024

Related Experiment Video

Updated: Jun 1, 2026

Discrimination of Seven Immune Cell Subsets by Two-fluorochrome Flow Cytometry
10:58

Discrimination of Seven Immune Cell Subsets by Two-fluorochrome Flow Cytometry

Published on: March 5, 2019

Conference Scene: T-cell subset phenotype and function.

Amy Hall1

  • 1School of Biology, University of Nottingham, Nottingham, NG7 2RD, UK. plxah10@nottingham.ac.uk

Immunotherapy
|June 15, 2011
PubMed
Summary

Research on T-cell subsets has advanced beyond the Th1-Th2 model, uncovering new subsets like regulatory T cells (Tregs) and Th17 cells. This meeting explored current knowledge and future directions in T-cell research for medical applications.

Area of Science:

  • Immunology
  • Cell Biology

Background:

  • The field of T-cell research has evolved significantly from the initial Th1-Th2 paradigm.
  • Recent discoveries include crucial T-cell subsets such as regulatory T cells (Tregs) and T helper 17 (Th17) cells.

Framework:

  • This meeting focused on the complex phenotype and function of diverse T-cell subsets.
  • It aimed to synthesize current understanding and identify knowledge gaps in T-cell subset research.

Implementation:

  • Researchers convened to discuss the latest findings and ongoing investigations in T-cell subset characterization.
  • The discussions provided insights into the methodologies and approaches used in this rapidly advancing field.

Implications:

  • Understanding T-cell subsets has profound implications for developing novel therapeutic strategies.

More Related Videos

Evaluation of T Follicular Helper Cells and Germinal Center Response During Influenza A Virus Infection in Mice
07:07

Evaluation of T Follicular Helper Cells and Germinal Center Response During Influenza A Virus Infection in Mice

Published on: June 27, 2020

Peptide:MHC Tetramer-based Enrichment of Epitope-specific T cells
13:58

Peptide:MHC Tetramer-based Enrichment of Epitope-specific T cells

Published on: October 22, 2012

Related Experiment Videos

Last Updated: Jun 1, 2026

Discrimination of Seven Immune Cell Subsets by Two-fluorochrome Flow Cytometry
10:58

Discrimination of Seven Immune Cell Subsets by Two-fluorochrome Flow Cytometry

Published on: March 5, 2019

Evaluation of T Follicular Helper Cells and Germinal Center Response During Influenza A Virus Infection in Mice
07:07

Evaluation of T Follicular Helper Cells and Germinal Center Response During Influenza A Virus Infection in Mice

Published on: June 27, 2020

Peptide:MHC Tetramer-based Enrichment of Epitope-specific T cells
13:58

Peptide:MHC Tetramer-based Enrichment of Epitope-specific T cells

Published on: October 22, 2012

  • This research holds potential for advancing treatments in various medical settings, particularly in immune-related diseases.