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Related Concept Videos

Clinical Trials: Overview01:11

Clinical Trials: Overview

Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
Pharmacovigilance01:19

Pharmacovigilance

Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
Drug Regulation01:25

Drug Regulation

Drug regulation encompasses the management of drug usage by evaluating its safety and efficacy through assessments conducted by regulatory authorities. Regrettably, the history of drug regulation is marred by several catastrophic events. One such incident is the Elixir Sulfanilamide tragedy, in which the toxic compound diethyl glycol was included in a sweet-tasting medication, leading to numerous fatalities. This event prompted the enactment of the Food, Drug, and Cosmetic Act in 1938. Under...
FDA Approved Drugs: Changes to Approved Drugs01:26

FDA Approved Drugs: Changes to Approved Drugs

Post-approval, manufacturers may modify an approved new or generic drug product. Such modifications can encompass alterations in the Active Pharmaceutical Ingredient (API), manufacturing process, formulation, batch size, manufacturing site, and container closure system (FDA Guidance for Industry, April 2004). Often, a drug product may undergo multiple changes.These modifications require careful evaluation to determine their potential impact on the drug product's identity, strength, quality,...
Bioequivalence studies: Biowaivers01:13

Bioequivalence studies: Biowaivers

In certain scenarios, in vitro dissolution tests can replace in vivo bioequivalence studies. This is particularly true when a drug product, though available in varying strengths, maintains proportional similarity in its active and inactive ingredients. In such cases, the need for in vivo bioequivalence studies for lower strength variants may be waived, provided dissolution tests and in vivo studies on the highest strength yield satisfactory results.Bioequivalence can be indicated through...
Preclinical Development: Overview01:28

Preclinical Development: Overview

Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...

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Closure of a Patent Foramen Ovale (PFO): An Intervention Sequence
10:52

Closure of a Patent Foramen Ovale (PFO): An Intervention Sequence

Published on: December 23, 2022

Patent review.

Anuradha Roy1, James E McGee

  • 1University of Kansas, Structural Biology Center, Lawrence, KS 66047, USA. anuroy@ku.edu.

Combinatorial Chemistry & High Throughput Screening
|June 15, 2011
PubMed
Summary
This summary is machine-generated.

This patent review covers key areas in drug discovery, including combinatorial chemistry and high throughput screening. It highlights patents relevant to drug repurposing and natural products for CCHTS readers.

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Area of Science:

  • Medicinal Chemistry
  • Drug Discovery
  • Intellectual Property Management

Background:

  • The field of drug discovery relies heavily on innovative chemical and biological screening techniques.
  • Intellectual property, particularly patents, plays a crucial role in protecting novel discoveries and enabling further research and development.
  • Understanding the patent landscape is essential for researchers and companies in the pharmaceutical and biotechnology sectors.

Purpose of the Study:

  • To provide a focused review of patents relevant to the readers of CCHTS (Combinatorial Chemistry and High Throughput Screening).
  • To identify and highlight significant patents in areas such as combinatorial chemistry, high throughput screening, drug repurposing, chemical libraries, high content screening, drug discovery, and natural products.
  • To offer insights into the intellectual property landscape shaping the future of drug discovery.

Main Methods:

  • A comprehensive patent search was conducted using a defined set of keywords.
  • Keywords included: combinatorial chemistry, high throughput screening, drug repurposing, chemical library, high content screening, drug discovery, and natural products.
  • Patents were identified and selected based on their relevance to the specified areas of interest and their issuance by recognized patent offices (WIPO or regional).

Main Results:

  • The review highlights patents across critical domains of modern drug discovery.
  • Key areas covered include the development and application of chemical libraries and screening technologies.
  • Emphasis is placed on patents related to drug repurposing strategies and the utilization of natural products.

Conclusions:

  • The patent landscape in drug discovery is dynamic, with significant activity in high throughput screening and combinatorial chemistry.
  • Drug repurposing and natural products represent growing areas of patentable innovation.
  • This review provides a valuable overview of recent patent activity for CCHTS readers, aiding in strategic research and development planning.