Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genomic characterization of ceftazidime/avibactam-resistant KPC-producing <i>Klebsiella pneumoniae</i> in bloodstream infections indicates OmpK35 and OmpK36 as pivotal key players in resistance mechanisms.

Frontiers in microbiology·2026
Same author

Social and Behavioral Correlates of Self-Perceived Psychological Distress in Celiac Disease During the COVID-19 Pandemic: An Exploratory Cross-Sectional Study (COVIMPACT).

Nutrients·2026
Same author

Dance/movement therapy in psychotic disorders and eating disorders: a systematic review.

Frontiers in psychiatry·2026
Same author

Preclinical Evidence for Antidepressant-like Effects of Histamine H3 Receptor Modulation: A Systematic Review and Meta-Analysis.

Life (Basel, Switzerland)·2026
Same author

Genomic characterization of ceftazidime/avibactam-resistant <i>Klebsiella pneumoniae</i>: a retrospective analysis on clinical isolates from an Italian transplant unit.

Frontiers in microbiology·2026
Same author

Association between unrecognized donor bloodstream infection and outcomes in solid organ transplant recipients: a prospective observational cohort study.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2026

Related Experiment Video

Updated: Jun 1, 2026

Assessment of Long-term Depression Induction in Adult Cerebellar Slices
09:30

Assessment of Long-term Depression Induction in Adult Cerebellar Slices

Published on: October 16, 2019

Cortical excitability changes associated with fixation-off sensitivity: a case report.

Gionata Strigaro1, Paolo Prandi, Claudia Varrasi

  • 1Section of Neurology, Department of Clinical and Experimental Medicine, University of Piedmont East A. Avogadro, Novara, Italy.

Epilepsia
|June 15, 2011
PubMed
Summary
This summary is machine-generated.

Fixation-off sensitivity (FOS) in epilepsy involves widespread cortical hyperexcitability. This study reveals impaired GABAergic inhibition and enhanced glutamatergic transmission during FOS, particularly in visual areas.

More Related Videos

Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury
09:49

Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury

Published on: January 20, 2023

Induction of an Isoelectric Brain State to Investigate the Impact of Endogenous Synaptic Activity on Neuronal Excitability In Vivo
10:19

Induction of an Isoelectric Brain State to Investigate the Impact of Endogenous Synaptic Activity on Neuronal Excitability In Vivo

Published on: March 31, 2016

Related Experiment Videos

Last Updated: Jun 1, 2026

Assessment of Long-term Depression Induction in Adult Cerebellar Slices
09:30

Assessment of Long-term Depression Induction in Adult Cerebellar Slices

Published on: October 16, 2019

Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury
09:49

Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury

Published on: January 20, 2023

Induction of an Isoelectric Brain State to Investigate the Impact of Endogenous Synaptic Activity on Neuronal Excitability In Vivo
10:19

Induction of an Isoelectric Brain State to Investigate the Impact of Endogenous Synaptic Activity on Neuronal Excitability In Vivo

Published on: March 31, 2016

Area of Science:

  • Neuroscience
  • Epileptology
  • Clinical Electrophysiology

Background:

  • "Fixation-off sensitivity" (FOS) is a unique human model for studying epileptic discharge mechanisms.
  • FOS is hypothesized to reflect widespread cortical hyperexcitability.
  • Understanding FOS pathophysiology can offer insights into specific epilepsy subtypes.

Observation:

  • Transcranial magnetic stimulation (TMS) and visual evoked potentials (VEPs) were used to assess cortical excitability in a patient with FOS.
  • Measurements were taken both during and outside of the FOS state.
  • The study focused on a 22-year-old female patient experiencing eyelid myoclonias and absences with generalized FOS.

Findings:

  • A persistently short cortical silent period indicated deficient GABA(B) inhibition, both within and outside FOS.
  • Short-interval intracortical inhibition, reflecting GABA(A) function, was also impaired.
  • The FOS state was characterized by enhanced intracortical facilitation (glutamate/aspartate transmission) and a significantly amplified afterdischarge in flash VEPs, suggesting overactivity in secondary visual areas.

Implications:

  • This single-case study provides electrophysiological evidence for imbalanced cortical excitability in FOS.
  • Findings suggest that impaired GABAergic and enhanced glutamatergic neurotransmission contribute to FOS.
  • The results highlight the role of both frontal and posterior cortical areas in this specific FOS subtype.