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Related Concept Videos

Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
Allergic Reactions02:06

Allergic Reactions

Overview
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Hypersensitivities01:30

Hypersensitivities

Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
Adrenergic Agonists: Therapeutic Uses01:30

Adrenergic Agonists: Therapeutic Uses

Adrenergic agonists have diverse therapeutic uses across various medical conditions and emergencies.
Emergency and Intensive Care Unit (ICU) applications: Pressor agents increase blood pressure, heart rate, and contractility in shock and organ failure situations. Dopamine can induce vasodilation and stimulate adrenoceptors. Endogenous catecholamines are effective in treating cardiogenic shock. α2-agonists like clonidine can reverse anesthesia-induced hypertension.
Allergies and anaphylaxis:...

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Related Experiment Video

Updated: Jun 1, 2026

Measuring Local Anaphylaxis in Mice
07:49

Measuring Local Anaphylaxis in Mice

Published on: October 14, 2014

Anaphylaxis: mechanisms and management.

J K Lee1, P Vadas

  • 1Division of Allergy and Clinical Immunology, St Michael's Hospital, University of Toronto, Toronto, ON, Canada.

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
|June 15, 2011
PubMed
Summary
This summary is machine-generated.

Anaphylaxis is a severe allergic reaction that requires prompt recognition and management. This review covers its epidemiology, diagnosis, mechanisms, and the latest treatment advances for healthcare professionals.

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Last Updated: Jun 1, 2026

Measuring Local Anaphylaxis in Mice
07:49

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Published on: October 14, 2014

Mouse Body Temperature Measurement Using Infrared Thermometer During Passive Systemic Anaphylaxis and Food Allergy Evaluation
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Published on: September 14, 2018

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Area of Science:

  • Allergy and Immunology
  • Clinical Medicine
  • Public Health

Background:

  • Anaphylaxis represents a critical medical emergency with potentially fatal outcomes.
  • Understanding its epidemiology and pathophysiology is crucial for effective clinical practice.

Purpose of the Study:

  • To provide a comprehensive literature review on anaphylaxis.
  • To focus on recent advancements in diagnosis and management.
  • To serve as a resource for clinicians, trainees, and researchers.

Main Methods:

  • Systematic literature review of epidemiological data.
  • Analysis of diagnostic criteria and established mechanisms.
  • Evaluation of current and emerging management strategies.

Main Results:

  • Anaphylaxis incidence and risk factors vary globally.
  • Standardized diagnostic criteria improve recognition.
  • Epinephrine remains the first-line treatment, with adjunctive therapies playing a role.

Conclusions:

  • Anaphylaxis necessitates a thorough understanding of its multifaceted aspects.
  • Continuous education and research are vital for improving patient outcomes.
  • Adherence to updated guidelines ensures optimal care for anaphylaxis patients.