Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Heterogeneity in epithelium-dependent responses.

K Stuart-Smith1

  • 1Department of Anaesthetics, Victoria Infirmary, Glasgow, United Kingdom.

Lung
|January 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A reply.

Anaesthesia·2013
Same author

Hemiarthroplasty performed under transversus abdominis plane block in a patient with severe cardiorespiratory disease.

Anaesthesia·2012
Same author

Fluid optimization guided by oesophageal Doppler significantly improves bowel perfusion.

British journal of anaesthesia·2011
Same author

CPR for the canary.

Anaesthesia·2004
Same author

Role of the endothelium and nitric oxide synthases in modulating superoxide formation induced by endotoxin and cytokines in porcine pulmonary arteries.

Thorax·2003
Same author

Demystified. Nitric oxide.

Molecular pathology : MP·2002
Same journal

Circulating Adipokines as Diagnostic and Prognostic Markers in Idiopathic Pulmonary Fibrosis.

Lung·2026
Same journal

Nebulised heparin as a treatment for lung diseases: formulation challenges and pulmonary drug delivery strategies.

Lung·2026
Same journal

Social Vulnerability Index is Associated with Increased Risk of Malignancy in Screen-Detected High-Risk Pulmonary Nodules.

Lung·2026
Same journal

Validation Approaches for Cough Monitoring Tools: A Scoping Review.

Lung·2026
Same journal

Serological Profiling and Neuro-Immune Resilience: The Dissociation Between Anti-SARS-CoV-2 Antibodies and Post-Viral Airway Hyperresponsiveness in Pediatric Asthma.

Lung·2026
Same journal

Salvinorin A Alleviates Bleomycin-Induced Pulmonary Fibrosis by Inhibiting M2 Macrophage Polarization and Macrophage-to-Myofibroblast Transition.

Lung·2026
See all related articles

The airway epithelium releases factors influencing bronchial smooth muscle. These epithelium-derived relaxing factors (EDRFs) show species-specific release patterns and are not nitric oxide.

Area of Science:

  • Pulmonary Medicine
  • Respiratory Physiology

Background:

  • The airway epithelium modulates bronchial smooth muscle tone.
  • Epithelium-derived factors (EDFs) are implicated in smooth muscle relaxation.
  • Heterogeneity exists in EDF effects across species and stimuli.

Purpose of the Study:

  • To investigate the release and characteristics of epithelium-derived relaxing factors (EDRFs).
  • To determine the influence of cholinergic tone on EDRF activity.
  • To elucidate the signaling pathways involved in EDRF action.

Main Methods:

  • In vitro studies on bronchial smooth muscle preparations.
  • Assessment of basal and stimulated release of EDRFs.
  • Pharmacological manipulation to assess signaling pathways (e.g., cyclic GMP).

Related Experiment Videos

Main Results:

  • Demonstrated both basal and stimulated release of EDRFs.
  • Observed species-specific variations in EDRF release patterns.
  • Found EDRF effects were most pronounced with high cholinergic tone.
  • Ruled out cyclic GMP and nitric oxide as mediators of EDRF action.

Conclusions:

  • The airway epithelium releases EDRFs that relax bronchial smooth muscle.
  • EDRF release and activity are species-dependent and modulated by cholinergic tone.
  • EDRFs represent a distinct class of relaxant mediators, separate from nitric oxide or cyclic GMP pathways.