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Related Concept Videos

Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
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Inflammation is a fundamental, protective biological response of vascularized tissues to cellular injury, infection, or harmful stimuli. Its primary function is to eliminate the initial cause of injury, clear necrotic cells and damaged tissue, and initiate the necessary repair processes.Cardinal SignsAcute inflammation presents with classic signs. Redness results from vasodilation and increased blood flow. Heat is due to increased metabolism and circulation. Swelling results from the...
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Acute inflammation produces a coordinated set of local and systemic changes that limit injury, eliminate pathogens, and initiate repair. These responses arise within minutes of infection, trauma, or chemical insult and are driven by vascular alterations and leukocyte-derived mediators. When the stimulus resolves, the reaction typically abates within days.Local EffectsAt the site of injury, arteriolar vasodilation increases blood flow, resulting in redness and warmth. Simultaneously, increased...
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Engineering Tendon Assembloids to Probe Cellular Crosstalk in Disease and Repair
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Published on: March 22, 2024

Tendinopathy and inflammation: some truths.

A Del Buono1, L Battery, V Denaro

  • 1Department of Orthopaedic and Trauma Surgery, Campus Biomedico University of Rome, Via Alvaro del Portillo, Rome, Italy.

International Journal of Immunopathology and Pharmacology
|June 15, 2011
PubMed
Summary

Overuse tendinopathies result from failed healing responses to tendon injuries. Conditions like obesity and diabetes impair immune function and collagen integrity, increasing risks for chronic tendon problems.

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Area of Science:

  • Orthopedics
  • Immunology
  • Metabolic Diseases

Background:

  • Overuse tendinopathies cause significant pain and disability, particularly in athletes.
  • Histological analysis reveals these conditions stem from a failed healing response to repetitive tendon stress.
  • Obesity and diabetes mellitus are implicated as risk factors due to their impact on immune cell availability and tissue metabolism.

Purpose of the Study:

  • To explore the underlying mechanisms linking metabolic conditions and systemic inflammation to failed tendon healing.
  • To understand how obesity and diabetes contribute to the development of chronic overuse tendinopathies.

Main Methods:

  • Review of histological findings in overuse tendinopathies.
  • Analysis of the immunological and metabolic alterations associated with obesity and diabetes.
  • Examination of the impact of systemic inflammation and insulin resistance on tendon repair.

Main Results:

  • Obesity reduces circulating immune cells, potentially impairing acute tendon injury responses.
  • Diabetes alters collagen properties, hindering enzymatic degradation and cross-linking, leading to chronic tendinopathy.
  • Chronic low-grade inflammation and insulin resistance are identified as key risk factors for failed tendon healing.

Conclusions:

  • Obesity and diabetes significantly increase the risk of developing chronic overuse tendinopathies.
  • These conditions compromise the body's ability to effectively heal tendon injuries.
  • Further research into novel therapeutic strategies targeting these underlying factors is warranted.