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Published on: June 21, 2019
Angiogenesis in hand chondroma: an immunohistochemical study
M L Ricciardella1, E D Rossi, G Fadda
1Department of Orthopedics, Catholic University of Rome, Italy.
Summary
Hand chondroma, a benign tumor with malignant features, shows vascular endothelial growth factor (VEGF) expression, suggesting its role in tumor aggressiveness. Other factors like PDGF and TGFβ2 are variably expressed, influencing tumor progression.
Area of Science:
- Orthopedics
- Oncology
- Pathology
Background:
- Hand chondroma presents as a benign clinical entity but exhibits malignant morphological characteristics.
- Understanding the ethiopathogenesis and immunohistochemical profile is crucial for managing hand chondromas.
Purpose of the Study:
- To investigate the expression of vascular endothelial growth factor (VEGF) and other markers in hand chondromas.
- To correlate immunohistochemical findings with tumor progression and angiogenesis.
- To explore the ethiopathogenesis and clinical significance of hand chondroma.
Main Methods:
- Immunohistochemical analysis of 8 hand chondroma cases treated with curettage.
- Assessment of VEGF, TGFβ2, PDGF, Ki-67, TNF, FGF1, and P53 expression.
Main Results:
- VEGF was expressed in all cases, indicating its potential role in early tumor aggressiveness.
- Transforming growth factor beta 2 (TGFβ2) and platelet-derived growth factor (PDGF) showed variable expression.
- Proliferation markers like Ki-67 were not consistently expressed, potentially explaining the low relapse rate after curettage.
Conclusions:
- VEGF expression may represent an initial stage of hand chondroma aggressiveness.
- Subsequent expression of PDGF and TGFβ2 might correlate with worsening morphological features.
- The variable expression of these markers and lack of proliferation indicators contribute to the low recurrence rate following adequate surgical removal.
