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Related Concept Videos

Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
Mitosis and Cytokinesis01:35

Mitosis and Cytokinesis

In eukaryotes, the cell division cycle is divided into distinct, coordinated cellular processes that include cell growth, DNA replication/chromosome duplication, chromosome distribution to daughter cells, and finally, cell division. The cell cycle is tightly regulated by its regulatory systems as well as extracellular signals that affect cell proliferation.
The processes of the cell cycle occur over approximately 24 hours (in typical human cells) and in two major distinguishable stages. The...
Mitosis and Cytokinesis02:03

Mitosis and Cytokinesis

In eukaryotes, the cell division cycle is divided into distinct, coordinated cellular processes that include cell growth, DNA replication/chromosome duplication, chromosome distribution to daughter cells, and finally, cell division. The cell cycle is tightly regulated by its regulatory systems as well as extracellular signals that affect cell proliferation.
The processes of the cell cycle occur over approximately 24 hours (in typical human cells) and in two major distinguishable stages. The...
Mitosis and Cytokinesis02:03

Mitosis and Cytokinesis

In eukaryotes, the cell division cycle is divided into distinct, coordinated cellular processes that include cell growth, DNA replication/chromosome duplication, chromosome distribution to daughter cells, and finally, cell division. The cell cycle is tightly regulated by its regulatory systems as well as extracellular signals that affect cell proliferation.
The processes of the cell cycle occur over approximately 24 hours (in typical human cells) and in two major distinguishable stages. The...
Mitosis And Cytokinesis01:35

Mitosis And Cytokinesis

In eukaryotes, the cell division cycle is divided into distinct, coordinated cellular processes that include cell growth, DNA replication/chromosome duplication, chromosome distribution to daughter cells, and finally, cell division. The cell cycle is tightly regulated by its regulatory systems as well as extracellular signals that affect cell proliferation.
The processes of the cell cycle occur over approximately 24 hours (in typical human cells) and in two major distinguishable stages. The...

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Preparation of Primary Acute Lymphoblastic Leukemia Cells in Different Cell Cycle Phases by Centrifugal Elutriation
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[Cell cycle, mitosis and therapeutic applications].

Antonin Levy1, Laurence Albiges-Sauvin, Christophe Massard

  • 1Institut Gustave-Roussy, service de radiothérapie oncologie, université Paris-XI, Villejuif, France. s.lheureux@baclesse.fr

Bulletin Du Cancer
|June 15, 2011
PubMed
Summary

Genomic DNA damage triggers cell cycle checkpoints and apoptosis. DNA repair pathways, including ATM/ATR signaling to CHK1/CHK2, maintain genome stability and are potential cancer therapeutic targets.

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Area of Science:

  • Molecular Biology
  • Genetics
  • Cell Biology

Background:

  • Genomic DNA faces constant threats from internal and external agents.
  • Unrepaired DNA damage can lead to mutations, cell death, and cancer.
  • Organisms have evolved sophisticated DNA repair mechanisms to maintain genome stability.

Purpose of the Study:

  • To investigate the cellular response pathways to DNA damage.
  • To identify key signaling molecules involved in DNA damage response.
  • To explore the therapeutic potential of targeting DNA damage response pathways in cancer.

Main Methods:

  • Analysis of DNA damage response pathways.
  • Investigation of cell cycle checkpoints and apoptosis induction.
  • Study of ATM and ATR signaling pathways and their downstream effectors CHK1 and CHK2.

Main Results:

  • DNA damage activates cell cycle checkpoints and apoptosis.
  • ATM and ATR kinases are crucial in responding to genotoxic stress.
  • CHK1 and CHK2 are key downstream targets in these signaling pathways.

Conclusions:

  • Cellular responses to DNA damage are critical for preventing mutations and cancer.
  • The ATM/ATR-CHK1/CHK2 signaling axis plays a vital role in maintaining genomic integrity.
  • Targeting these pathways offers promising therapeutic strategies for cancer treatment.