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Hemagglutination by herpes simplex virus type 1
E Trybała1, Z Larski, J Wiśniewski
1Department of Veterinary Microbiology, Faculty of Veterinary Medicine, Academy of Agriculture and Technology, Olsztyn, Poland.
Archives of Virology
|January 1, 1990
Abstract:
The McIntyre and HSZP strains as well as clinical isolate of herpes simplex virus type 1 were found to agglutinate C57Bl/10su and CBA mouse red blood cells. The hemagglutinating activity was inhibited by antisera that neutralized the infectivity of the virus.
Insights
Herpes simplex virus type 1 (HSV-1) can agglutinate mouse red blood cells. This viral hemagglutinating activity is neutralized by specific antisera, indicating a link to infectivity.
Area of Science:
- Virology
- Immunology
Background:
- Herpes simplex virus type 1 (HSV-1) is a common human pathogen.
- Understanding viral interactions with host cells is crucial for disease control.
Purpose of the Study:
- To investigate the hemagglutinating properties of HSV-1.
- To determine if hemagglutination is related to viral infectivity.
Main Methods:
- Testing the agglutination of C57Bl/10su and CBA mouse red blood cells by HSV-1 strains (McIntyre, HSZP, and clinical isolate).
- Assessing the effect of antisera, known to neutralize HSV-1 infectivity, on hemagglutination.
Main Results:
- HSV-1 strains, including a clinical isolate, demonstrated the ability to agglutinate specific mouse red blood cells.
- The hemagglutinating activity of HSV-1 was effectively inhibited by antisera that neutralized viral infectivity.
Conclusions:
- HSV-1 possesses hemagglutinating properties.
- The observed hemagglutination is linked to the infectivity of the virus, suggesting potential diagnostic or therapeutic targets.