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Solid-phase Submonomer Synthesis of Peptoid Polymers and their Self-Assembly into Highly-Ordered Nanosheets
Published on: November 2, 2011
The effect of neat ionic liquid on the folding of short peptides
Jia Lin Huang1, Michael E Noss1, Karson M Schmidt1
1Department of Chemistry, The College of New Jersey, 2000 Pennington Rd., Ewing, NJ 08628, USA. bunagan@tcnj.edu.
Chemical Communications (Cambridge, England)
|June 15, 2011
Abstract:
Using circular dichroism spectroscopy, we show evidence of unusual folding behaviour for several designed peptides in neat ionic liquid. Helical peptides, AKA(2) and Trp-cage, exhibit heat-induced folding, with stable helical structure persisting to 96 °C, whereas the β-hairpin Trpzip4 is destabilized by the neat [C(4)mpy][Tf(2)N].
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