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Carnosine as a potential scavenger of oxidants generated by stimulated neutrophils
B P Sharonov1, Govorova NJu, S N Lyzlova
1All Union Research Institute of Highly Pure Biopreparations, Leningrad, USSR.
Biochemistry International
|January 1, 1990
Abstract:
Luminol-dependent chemiluminescence of PMA-stimulated human neutrophils decrease more than by 50% in the presence of physiological concentrations of carnosine (20 mM). This inhibition is the result of carnosine ability to scavenge hypochlorite (OCl-), since carnosine exerts a similar effect on chemiluminescence produced by myeloperoxidase-H2O2-Cl- and OCl(-)-H2O2 systems. The previously undocumented property of this dipeptide to scavenge active oxygen species requires further experiments.