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High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals

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CT-based myocardial perfusion imaging-practical considerations: acquisition, image analysis, interpretation, and

Vishal C Mehra¹, Marietta Ambrose, Carolina Valdiviezo-Schlomp

¹Department of Medicine, Division of Cardiology, Johns Hopkins University, 600 N. Wolfe Street, Carnegie Building 565C, Baltimore, MD 21287, USA.

Journal of Cardiovascular Translational Research

|June 15, 2011

Summary

New CT-based myocardial perfusion imaging (CTP), combined with CT angiography (CTA), offers a comprehensive, non-invasive cardiac risk assessment strategy. This approach integrates anatomical and functional data for improved patient stratification.

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Cardiac Magnetic Resonance for the Evaluation of Suspected Cardiac Thrombus: Conventional and Emerging Techniques

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Published on: June 11, 2019

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High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals

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Published on: December 16, 2022

Cardiac Magnetic Resonance for the Evaluation of Suspected Cardiac Thrombus: Conventional and Emerging Techniques

Cardiac Magnetic Resonance for the Evaluation of Suspected Cardiac Thrombus: Conventional and Emerging Techniques

Published on: June 11, 2019

Area of Science:

Cardiology
Radiology
Medical Imaging

Background:

Non-invasive cardiac risk assessment traditionally uses exercise or pharmacological stress testing.
CT angiography (CTA) effectively differentiates coronary artery disease risk.
Advancements in CT technology enable CT-based myocardial perfusion imaging (CTP) for functional assessment.

Purpose of the Study:

To review the research, implementation, and analysis methods for CT-based myocardial perfusion imaging (CTP).
To discuss the current technological state and challenges of CTP.
To highlight the integration of CTA and CTP in multicenter studies like CORE320 for comprehensive risk assessment.

Main Methods:

Review of existing literature on CT-based cardiac risk assessment modalities.
Discussion of quantitative, semiquantitative, and qualitative image analysis techniques for CTP.
Examination of the CORE320 study evaluating combined CTA and CTP against reference standards.

Main Results:

CTP provides functional information complementing anatomical data from CTA.
Combined CTA and CTP strategies show promise for comprehensive cardiac risk assessment.
The CORE320 study investigates this combined approach against established methods.

Conclusions:

CT-based myocardial perfusion imaging (CTP) represents a significant advancement in non-invasive cardiac risk assessment.
Integrating CTA and CTP offers a powerful, comprehensive strategy for evaluating coronary artery disease.
Further research and validation, such as through the CORE320 study, are crucial for widespread clinical adoption.