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Related Concept Videos

T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
Inflammatory Response01:28

Inflammatory Response

An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...

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Related Experiment Video

Updated: Jun 1, 2026

Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity
10:10

Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity

Published on: November 8, 2016

CD8(+) Tregs in autoimmunity: learning "self"-control from experience.

Sue Tsai1, Xavier Clemente-Casares, Pere Santamaria

  • 1Julia McFarlane Diabetes Research Centre, The University of Calgary, AB, Canada.

Cellular and Molecular Life Sciences : CMLS
|June 15, 2011
PubMed
Summary
This summary is machine-generated.

Autoreactive CD8(+) regulatory T cells (Tregs) modulate immune responses. The study suggests autoimmunity drives CD8(+) Treg development, offering a potential therapeutic target for autoimmune diseases.

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Last Updated: Jun 1, 2026

Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity
10:10

Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity

Published on: November 8, 2016

Generation of Induced Regulatory T Cells from Primary Human Naïve and Memory T Cells
14:23

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Published on: April 16, 2012

Adenoviral Transduction of Naive CD4 T Cells to Study Treg Differentiation
15:33

Adenoviral Transduction of Naive CD4 T Cells to Study Treg Differentiation

Published on: August 13, 2013

Area of Science:

  • Immunology
  • Autoimmunity
  • T cell regulation

Background:

  • Autoreactive CD8(+) regulatory T cells (Tregs) are crucial for immune self-tolerance.
  • Defects in CD8(+) Tregs are associated with autoimmune diseases.
  • The origin and function of CD8(+) Treg subsets in autoimmunity are not fully understood.

Purpose of the Study:

  • To explore the role of the autoimmune process in the development of autoregulatory CD8(+) T cells.
  • To propose a model for how chronic autoantigen exposure shapes CD8(+) Treg populations.
  • To identify potential therapeutic strategies for autoimmunity based on Treg modulation.

Main Methods:

  • Review of existing evidence on CD8(+) Treg function and autoimmunity.
  • Hypothesis generation based on immunological principles.
  • In silico modeling (implied).

Main Results:

  • Evidence suggests that the autoimmune process itself can promote the development of autoregulatory CD8(+) T cells.
  • Chronic autoantigen exposure may drive the differentiation of non-pathogenic autoreactive CD8(+) T cells into memory-like autoregulatory cells.
  • This creates a negative feedback loop to control pathogenic autoreactive T cells.

Conclusions:

  • The autoimmune process can foster the development of CD8(+) regulatory T cells.
  • Boosting autoregulatory T cell memory may offer a strategy to treat autoimmunity without impairing overall immunity.