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Related Experiment Video

Updated: Jun 1, 2026

Analysis of Nephron Composition and Function in the Adult Zebrafish Kidney
08:53

Analysis of Nephron Composition and Function in the Adult Zebrafish Kidney

Published on: August 9, 2014

Zebrafish kidney development: basic science to translational research.

Lisa M Swanhart1, Chiara Cianciolo Cosentino, Cuong Q Diep

  • 1Department of Developmental Biology, University of Pittsburgh, Pennsylvania 15213, USA.

Birth Defects Research. Part C, Embryo Today : Reviews
|June 15, 2011
PubMed
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Zebrafish models advance understanding of kidney diseases like ciliopathies and acute kidney injury (AKI). Studies highlight zebrafish renal stem cells, paving the way for new kidney therapeutics and drug discovery.

Area of Science:

  • Developmental Biology
  • Nephrology
  • Genetics

Background:

  • The zebrafish (Danio rerio) is a valuable model for studying kidney development and disease due to its simple embryonic kidney structure.
  • Zebrafish research has significantly contributed to understanding kidney-related ciliopathies and acute kidney injury (AKI).

Purpose of the Study:

  • To review the role of zebrafish as a model for human kidney-related ciliopathies and acute kidney injury (AKI).
  • To highlight how zebrafish studies are advancing the understanding of these complex kidney pathologies and facilitating drug discovery.

Main Methods:

  • Analysis of gene function in zebrafish models for human kidney diseases.
  • Identification and characterization of renal progenitor (stem) cells in adult zebrafish.

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Published on: July 17, 2016

Acute Kidney Injury Model Induced by Cisplatin in Adult Zebrafish
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Acute Kidney Injury Model Induced by Cisplatin in Adult Zebrafish

Published on: May 15, 2021

Related Experiment Videos

Last Updated: Jun 1, 2026

Analysis of Nephron Composition and Function in the Adult Zebrafish Kidney
08:53

Analysis of Nephron Composition and Function in the Adult Zebrafish Kidney

Published on: August 9, 2014

Nephrotoxin Microinjection in Zebrafish to Model Acute Kidney Injury
07:58

Nephrotoxin Microinjection in Zebrafish to Model Acute Kidney Injury

Published on: July 17, 2016

Acute Kidney Injury Model Induced by Cisplatin in Adult Zebrafish
13:25

Acute Kidney Injury Model Induced by Cisplatin in Adult Zebrafish

Published on: May 15, 2021

Main Results:

  • Zebrafish studies have been instrumental in analyzing gene function related to human ciliopathies.
  • A renal progenitor cell crucial for kidney regeneration in zebrafish has been identified, relevant to both normal lifespan and injury response.

Conclusions:

  • Zebrafish serve as a successful model for studying a wide range of human kidney diseases, including ciliopathies and AKI.
  • The zebrafish model holds significant promise for future kidney drug discovery and therapeutic development.